Is Hydralazine Hydrochloride compatible with breastfeeding? Do we have alternatives for Hydralazine Hydrochloride?

Hydralazine Hydrochloride

March 29, 2016 (Very Low Risk)

It is excreted into breast milk in clinically non-significant amount. No problem was observed in infants whose mothers were on this medication.
Plasma levels in those infants were undetectable or very low.

The American Academy of Pediatrics rates it as a medication usually compatible with breastfeeding.
WHO List of Essential Medicines 2002: compatible with breastfeeding.

Alternatives

We do not have alternatives for Hydralazine Hydrochloride since it is relatively safe.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Writings

  • Υδραλαζίνη υδροχλωρική (Greek)
  • Гидралазина Гидрохлорид (Cyrillic)
  • ヒドララジン塩酸塩 (Japanese)
  • C8 H8 N4, HCl (Molecular formula)

Drug trade names

References

  1. Anderson PO. Treating Hypertension During Breastfeeding. Breastfeed Med. 2018Abstract
  2. Malachias MV, Figueiredo CE, Sass N, Antonello IC, Torloni MR, Bortolotto MRF L. 7th Brazilian Guideline of Arterial Hypertension: Chapter 9 - Arterial Hypertension in pregnancy Arq Bras Cardiol. 2016Abstract Full text (link to original source) Full text (in our servers)
  3. Magee LA, Lowe S, Douglas MJ, Kathirgamanathan A. Therapeutics and anaesthesia. Best Pract Res Clin Obstet Gynaecol. 2011Abstract
  4. Ghanem FA, Movahed A. Use of antihypertensive drugs during pregnancy and lactation. Cardiovasc Ther. 2008Abstract Full text (link to original source) Full text (in our servers)
  5. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)
  6. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001Abstract Full text (link to original source) Full text (in our servers)
  7. Franke G, Pietsch P, Schneider T, Siegmund W, Grabow D, Schütz H. Studies on the kinetics and distribution of dihydralazine in pregnancy. Biol Res Pregnancy Perinatol. 1986Abstract
  8. Liedholm H, Wåhlin-Boll E, Hanson A, Ingemarsson I, Melander A. Transplacental passage and breast milk concentrations of hydralazine. Eur J Clin Pharmacol. 1982Abstract