Is Hypromellose compatible with breastfeeding? Do we have alternatives for Hypromellose?


August 29, 2018 (Very Low Risk)

Semisynthetic, inert and viscoelastic polymer with thickener, bioadhesive and solubility enhancing properties.
It is used as a medicine coating to modify its intestinal release and prolong its effect,
Used as a lubricant in the form of eye drops.

At the date of last update, we did not find published data on its excretion in breast milk.

Since it is a derivative of cellulose, it is not absorbed either in the intestine or as an ophthalmological preparation (AEMPS 2014, MHRA 2009), so it is highly unlikely to appear in breast milk.
Its high molecular weight (Fukasawa 2004) still makes its excretion in milk less possible.

It is an inert product that is not metabolized and is devoid of toxicity, lacking systemic side effects (AEMPS 2014).


We do not have alternatives for Hypromellose since it is relatively safe.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.


  • Artificial Tears
  • Carboxyméthylcellulose
  • Carmellose
  • Hydroxypropylmethylcellulose
  • Hypromellose Acetate Succinate
  • Hypromellose Phthalate


  • Λοίμωξη Μητέρας από Χλαμύδια (Greek)
  • Υπρομελλόζη (Greek)
  • هيبروميلوز (Arabic)
  • Гипромеллоза (Cyrillic)
  • 羟丙甲纤维素 (Chinese)
  • ヒプロメロース (Japanese)
  • S01KA02 (ATC Code/s)


  1. AEMPS-Stada. Hipromelosa. Ficha técnica. 2014
  2. MHRA. Hypromellose. Drug Summary. 2009 Full text (in our servers)
  3. Fukasawa M, Obara S. Molecular weight determination of hypromellose acetate succinate (HPMCAS) using size exclusion chromatography with a multi-angle laser light scattering detector. Chem Pharm Bull (Tokyo). 2004Abstract