Is Inositol compatible with breastfeeding? Do we have alternatives for Inositol?

Inositol

June 4, 2016 (Very Low Risk)

Product of natural origin and glucose isomer which is present in cereals, fruits, nuts and vegetables, as well as animal offal and milk. It is metabolized to glucose.
Considered as part of vitamin B (Bh) with no clear evidence of its activity as such or signs of deficiency.

It is found in breast milk. A higher concentration in the plasma of newborns than that in their mothers has been found. Breastfed infants show higher plasma levels of Inositol than formula-fed ones or after parenteral nutrition.
It has been used in the newborn period to treat lung disorders and retinopathy associated to prematurity.

No clear therapeutic indications nor cases of overdose poisoning with this product are known.

Alternatives

We do not have alternatives for Inositol since it is relatively safe.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • Cyclohexanhexol
  • Cyclohexitol
  • Mesoinositol
  • Myoinositol

Writings

  • Инозитол (Cyrillic)
  • イノシトール (Japanese)
  • C6H12O6 (Molecular formula)

Drug trade names

References

  1. Fang JL, Sorita A, Carey WA, Colby CE, Murad MH, Alahdab F. Interventions To Prevent Retinopathy of Prematurity: A Meta-analysis. Pediatrics. 2016Abstract
  2. AESAN. Informe del Comité Científico de la Agencia Española de Seguridad Alimentaria y Nutrición (AESAN) sobre condiciones de uso de determinadas sustancias distintas de vitaminas, minerales y plantas para ser empleadas en complementos alimenticios - 1. Revista del comité científico nº 17. 2012 Full text (in our servers)
  3. Brown LD, Cheung A, Harwood JE, Battaglia FC. Inositol and mannose utilization rates in term and late-preterm infants exceed nutritional intakes. J Nutr. 2009Abstract
  4. Huisman M, van Beusekom CM, Lanting CI, Nijeboer HJ, Muskiet FA, Boersma ER. Triglycerides, fatty acids, sterols, mono- and disaccharides and sugar alcohols in human milk and current types of infant formula milk. Eur J Clin Nutr. 1996Abstract
  5. Hallman M, Bry K, Hoppu K, Lappi M, Pohjavuori M. Inositol supplementation in premature infants with respiratory distress syndrome. N Engl J Med. 1992Abstract
  6. Pereira GR, Baker L, Egler J, Corcoran L, Chiavacci R. Serum myoinositol concentrations in premature infants fed human milk, formula for infants, and parenteral nutrition. Am J Clin Nutr. 1990Abstract Full text (link to original source)
  7. Jenness R. The composition of human milk. Semin Perinatol. 1979Abstract