Is Lactase compatible with breastfeeding? Do we have alternatives for Lactase?

Lactase

November 24, 2016 (Very Low Risk)

Enzyme which is composed by more than 1.000 amino acids that hydrolyzes Lactose into Glucose and Galactose. It is produced in larger quantity by intestinal cells of newborns and infants than older children and adults, in order to digest the milk sugar or Lactose. Depending on type of populations, only 30 to 70% of individuals can continue producing intestinal lactose in later ages.

At latest update information was not found on excretion into breast milk, but, because it's proteic nature it would be digested before absorption, all that along with a high molecular weight makes excretion intro breast milk highly unlikely.

In addition, it is not toxic since it has been used, with no effectiveness, for treatment of colicky pain in infants without side-effects reported.

Alternatives

We do not have alternatives for Lactase since it is relatively safe.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • チラクターゼ
  • Tilactase
  • تيلاكتاز
  • β-Galactosidase
  • Тилактаза
  • 半乳糖苷酶

Drug trade names

References

  1. Krüttli A, Bouwman A, Akgül G, Della Casa P, Rühli F, Warinner C. Ancient DNA analysis reveals high frequency of European lactase persistence allele (T-13910) in medieval central europe. PLoS One. 2014Abstract
  2. [No authors listed] Management of infantile colic. Drug Ther Bull. 2013Abstract
  3. Hall B, Chesters J, Robinson A. Infantile colic: a systematic review of medical and conventional therapies. J Paediatr Child Health. 2012Abstract
  4. Critch J. Infantile colic: Is there a role for dietary interventions? Paediatr Child Health. 2011Abstract
  5. Bersaglieri T, Sabeti PC, Patterson N, Vanderploeg T, Schaffner SF, Drake JA, Rhodes M, Reich DE, Hirschhorn JN. Genetic signatures of strong recent positive selection at the lactase gene. Am J Hum Genet. 2004Abstract
  6. Royer P. Breast feeding and biological development. Acta Paediatr Scand. 1978Abstract