Is Lepirudin compatible with breastfeeding? Do we have alternatives for Lepirudin?

Lepirudin

October 27, 2014 (Low Risk)

Hirudin is a 65 aminoacid-containing protein that has a direct inhibitory effect on thrombin, which is extracted from leech. Due to a higher molecular weight, excretion to breast milk and absorption are unlikely.

Alternatives

We do not have alternatives for Lepirudin.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • Recombinant Hirudin

Drug trade names

References

  1. Lindhoff-Last E, Willeke A, Thalhammer C, Nowak G, Bauersachs R. Hirudin treatment in a breastfeeding woman. Lancet. 2000Abstract