Is Levodropropizine compatible with breastfeeding? Do we have alternatives for Levodropropizine?

Levodropropizine

February 19, 2015 (Low Risk)

Non-opioid cough relief medication.

At latest update, relevant published data on excretion into breast milk were not found.

Pharmacokinetic characteristics (low molecular weight, low protein-binding capacity) would favour that it may be excreted into breast milk in significant amount.

Until more information on it is available, safer options are preferred, especially when the infant is a newborn or in case of prematurity.

Otherwise whenever used, the lower effective dose as possible and for the shortest time is recommended. Follow-up for somnolence and feeding troubles should be warranted.

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • レボドロプロピジン
  • DF-526
  • ليفودروبروبيزين
  • Леводропропизин
  • 左羟丙哌嗪

Drug trade names

References

  1. AEMPS. Levodropropizina. Ficha técnica. 2014 Full text (in our servers)
  2. Levodropropizine. Drug Summary. 2014 Full text (in our servers)
  3. Jang JW, Seo JH, Jo MH, Lee YJ, Cho YW, Yim SV, Lee KT. Relative bioavailability of levodropropizine 60 mg capsule and syrup formulations in healthy male Korean volunteers: a singledose, randomized-sequence, open-label, two-way crossover study. Int J Clin Pharmacol Ther. 2013Abstract
  4. Sangil Jeon, Jongtae Lee, Taegon Hong, Jeongki Paek, Seunghoon Han, Dong-Seok Yim. Pharmacokinetics and Safety of Levodropropizine Controlled Release Tablet after Repeated Dosing in Healthy Male Volunteers. J Korean Soc Clin Pharmacol Ther 2013;21(2):113-119. 2013 Full text (link to original source) Full text (in our servers)
  5. Banderali G, Riva E, Fiocchi A, Cordaro CI, Giovannini M. Efficacy and tolerability of levodropropizine and dropropizine in children with non-productive cough. J Int Med Res. 1995Abstract