Is Lincomycin compatible with breastfeeding? Do we have alternatives for Lincomycin?

Lincomycin

July 11, 2016 (Very Low Risk)

A Lincosamide type antibacterial drug which is structurally similar to clindamycin.

As clindamycin, it is excreted in breast milk in clinically non-significant amount with no problems being reported in infants whose mothers were treated with it.

Its low oral bioavailability that further decreases with simultaneous ingestion of food, hinders the drug passage to the infant plasma from ingested mother’s milk , except in preterm babies and immediate neonatal period, in which they may occur an increased intestinal permeability.

Among infants whose mothers are treated with antibiotics, an alteration of the intestinal flora may appear. In case of infant's fever, the possibility of false negative results of bacterial cultures should be taken into account.

Alternatives

We do not have alternatives for Lincomycin since it is relatively safe.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • Lincomycin Hydrochloride

Writings

  • Λινκομυκίνη (Greek)
  • لينكوميسين (Arabic)
  • Линкомицин (Cyrillic)
  • 林可霉素 (Chinese)
  • リンコマイシン (Japanese)
  • C18H34N2O6S (Molecular formula)

References

  1. Amir LH, Pirotta MV, Raval M. Breastfeeding--evidence based guidelines for the use of medicines. Aust Fam Physician. 2011Abstract Full text (link to original source) Full text (in our servers)
  2. Stéen B, Rane A. Clindamycin passage into human milk. Br J Clin Pharmacol. 1982Abstract Full text (link to original source) Full text (in our servers)
  3. Wilson JT. Milk/plasma ratios and contraindicated drugs. In: Wilson JT, ed. Drugs in Breast Milk. Balgowlah, Australia: ADIS Press: 78–9. 1981
  4. MEDINA A, FISKE N, HJELT-HARVEY I, BROWN CD, PRIGOT A. ABSORPTION, DIFFUSION, AND EXCRETION OF A NEW ANTIBIOTIC, LINCOMYCIN. Antimicrob Agents Chemother (Bethesda). 1963Abstract