Second generation anti-histaminic drug with low sedative effect.
Excreted in non-significant amount into breast milk (Hilbert 1988). No side effects were observed in breastfed infants of treated mothers (Merlob 2002).
Various medical societies and expert consensus consider the use of this medication safe during breastfeeding (Butler 2014, Amir 2011, So 2010, Leachman 2006, National Asthma Ed. 2004, Solhaug 2004, Mitchell 1999, Ghaeli 1993).
The British Society of Immunology and Allergy rates it compatible with breastfeeding (Powell 2007).
American Academy of Pediatrics: medication usually compatible with breastfeeding (AAP 2001).
We do not have alternatives for Loratadine since it is relatively safe.
Very Low Risk
Compatible. Not risky for breastfeeding or infant.
Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.
Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.
Very High Risk
Not recommended. Cessation of breastfeeding or alternative.
- Λοραταδίνη (Greek)
- لوراتادين (Arabic)
- Лоратадин (Cyrillic)
- 氯雷他定 (Chinese)
- ロラタジン (Japanese)
- C22 H23 ClN2 O2 (Molecular formula)
- Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate (Chemical name)
- R06AX13 (ATC Code/s)
Drug trade names
- Butler DC, Heller MM, Murase JE. Safety of dermatologic medications in pregnancy and lactation: Part II. Lactation. J Am Acad Dermatol. 2014Abstract
- So M, Bozzo P, Inoue M, Einarson A. Safety of antihistamines during pregnancy and lactation. Can Fam Physician. 2010Abstract Full text (link to original source) Full text (in our servers)
- Powell RJ, Du Toit GL, Siddique N, Leech SC, Dixon TA, Clark AT, Mirakian R, Walker SM, Huber PA, Nasser SM; British Society for Allergy and Clinical Immunology (BSACI). BSACI guidelines for the management of chronic urticaria and angio-oedema. Clin Exp Allergy. 2007Abstract Full text (link to original source) Full text (in our servers)
- Leachman SA, Reed BR. The use of dermatologic drugs in pregnancy and lactation. Dermatol Clin. 2006Abstract
- Solhaug V, Roland PD. Bruk av antihistaminer under graviditet og amming \ [Use of antihistaminics during pregnancy and breast feeding]. Tidsskr Nor Laegeforen. 2004Abstract Full text (link to original source) Full text (in our servers)
- National Asthma Education and Prevention Program Asthma and Pregnancy Working Group. Managing asthma during pregnancy: recommendations for pharmacologic treatment-2004 update. 2004;1-57. 2004 Full text (link to original source) Full text (in our servers)
- Merlob P, Stahl B. Prospective follow-up of adverse reactions in breast-fed infants exposed to loratadine treatment (1999-2001). BELTIS Newsl. 2002;Number 10:43-51 (in Lactmed) 2002 Full text (in our servers)
- AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001Abstract Full text (link to original source) Full text (in our servers)
- Mitchell JL. Use of cough and cold preparations during breastfeeding. J Hum Lact. 1999Abstract
- Ghaeli P, Kaufman MB. Oral antihistamines/decongestants and breastfeeding. J Hum Lact. 1993Abstract
- Hilbert J, Radwanski E, Affrime MB, Perentesis G, Symchowicz S, Zampaglione N. Excretion of loratadine in human breast milk. J Clin Pharmacol. 1988Abstract