Is Misoprostol compatible with breastfeeding? Do we have alternatives for Misoprostol?

Misoprostol

July 11, 2016 (Very Low Risk)

Prostaglandin E1 analogue that is used in the prevention of gastroduodenal ulcers associated with the use of NSAIDs and induction of labor and abortion provocation.

It is found naturally in milk and colostrum.

It is excreted in breast milk in clinically non-significant amount with a very short half-life span.

Follow-up for intestinal colic or diarrhea in the infant.

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • ミソプロストール
  • ميسوبروستول
  • μισοπροστόλη
  • Мизопростол
  • 米索前列醇

Drug trade names

References

  1. FLASOG. Uso del Misoprostol en Obstetricia y Ginecología. Monografía. 2013 Full text (in our servers)
  2. Sääv I, Fiala C, Hämäläinen JM, Heikinheimo O, Gemzell-Danielsson K. Medical abortion in lactating women--low levels of mifepristone in breast milk. Acta Obstet Gynecol Scand. 2010Abstract
  3. Guerra GV, Cecatti JG, Souza JP, Faúndes A, Morais SS, Gülmezoglu AM, Parpinelli MA, Passini R Jr, Carroli G; World Health Organisation 2005 Global Survey on Maternal and Perinatal Health Research Group. Factors and outcomes associated with the induction of labour in Latin America. BJOG. 2009Abstract Full text (link to original source) Full text (in our servers)
  4. Misoprostol. Data Sheet. 2009 Full text (in our servers)
  5. Vogel D, Burkhardt T, Rentsch K, Schweer H, Watzer B, Zimmermann R, Von Mandach U. Misoprostol versus methylergometrine: pharmacokinetics in human milk. Am J Obstet Gynecol. 2004Abstract
  6. Abdel-Aleem H, Villar J, Gülmezoglu AM, Mostafa SA, Youssef AA, Shokry M, Watzer B. The pharmacokinetics of the prostaglandin E1 analogue misoprostol in plasma and colostrum after postpartum oral administration. Eur J Obstet Gynecol Reprod Biol. 2003Abstract
  7. Shimizu T, Yamashiro Y, Yabuta K. Prostaglandin E1, E2, and F2 alpha in human milk and plasma. Biol Neonate. 1992Abstract
  8. Bremme K, Eneroth P, Bygdeman M. Maternal serum hormone changes during abortion induced with 16,16-dimethyl-trans-delta 2-PGE1 methyl ester. Prostaglandins Leukot Med. 1982Abstract