Is Moclobemide compatible with breastfeeding? Do we have alternatives for Moclobemide?

Moclobemide

April 21, 2015 (Very Low Risk)

Excreted into breast milk in a clinically non-significant amount.

No clinical untoward effects on the physical and psychomotor development of the infants at both short and long-term basis.

Some reports of galactorrhea have been described.

Because there is less published experience with this drug than with others, an alternative known to be safer should be preferred mostly during the neonatal period or prematurity.

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • モクロベミド
  • موكلوبيميد
  • μοκλοβεμίδη
  • Моклобемид

Drug trade names

References

  1. MHRA. Moclobemide. Drug Summary. 2014 Full text (in our servers)
  2. AEMPS. Moclobemida. Ficha técnica. 2011 Full text (in our servers)
  3. Taylor T, Kennedy D. Safety of moclobemide in pregnancy and lactation, four case reports. Birth Defects Research Part A- Clinical and Molecular Teratology. 2008;82:413. 2008
  4. Dunn NR, Freemantle SN, Pearce GL, Mann RD. Galactorrhoea with moclobemide. Lancet. 1998Abstract
  5. Håberg M, Matheson I. [Antidepressive agents and breast feeding]. Tidsskr Nor Laegeforen. 1997Abstract
  6. Juruena MF, Pires ML, Calil HM. Moclobemide effects on prolactin plasma levels in healthy individuals: the hormonal increase induced by a single dose is maintained during a 4-week period of drug intake. Int Clin Psychopharmacol. 1997Abstract
  7. Nair NP, Ahmed SK, Kin NM. Biochemistry and pharmacology of reversible inhibitors of MAO-A agents: focus on moclobemide. J Psychiatry Neurosci. 1993Abstract Full text (link to original source) Full text (in our servers)
  8. Pons G, Schoerlin MP, Tam YK, Moran C, Pfefen JP, Francoual C, Pedarriosse AM, Chavinie J, Olive G. Moclobemide excretion in human breast milk. Br J Clin Pharmacol. 1990Abstract Full text (link to original source) Full text (in our servers)