Is Mupirocin compatible with breastfeeding? Do we have alternatives for Mupirocin?

Mupirocin

November 17, 2014 (Very Low Risk)

Because of a small dose used and low absorption through skin (less than 1%), excretion into breast milk in significant amount is unlikely.

Despite of it is well absorbed by the gut, it is rapidly and completely metabolized into Monic acid which is a non-active metabolite. However, whenever used on the nipple, it is recommended remove excess of cream by using a gauze.

Effectiveness is not higher than purified Lanolin for treatment of sore or cracked nipples. Results in the treatment of nipple infection due to Staph. aureus are less encouraging than with the use of oral antibiotics.

Caution should be observed with the application of creams, gels and other products that are indicated for local use if they contain paraffin (Mineral oil) to avoid absorption by the infant.

Alternatives

We do not have alternatives for Mupirocin since it is relatively safe.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • ムピロシン
  • Pseudomonic Acid
  • موبيروسين
  • μουπιροκίνη
  • Мупироцин
  • 莫匹罗星

Drug trade names

References

  1. Dennis CL, Schottle N, Hodnett E, McQueen K. An all-purpose nipple ointment versus lanolin in treating painful damaged nipples in breastfeeding women: a randomized controlled trial. Breastfeed Med. 2012Abstract
  2. Concin N, Hofstetter G, Plattner B, Tomovski C, Fiselier K, Gerritzen K, Fessler S, Windbichler G, Zeimet A, Ulmer H, Siegl H, Rieger K, Concin H, Grob K. Mineral oil paraffins in human body fat and milk. Food Chem Toxicol. 2008Abstract
  3. AEMPS. Mupirocina. Ficha técnica. 2007 Full text (in our servers)
  4. Leachman SA, Reed BR. The use of dermatologic drugs in pregnancy and lactation. Dermatol Clin. 2006Abstract
  5. Noti A, Grob K, Biedermann M, Deiss U, Brüschweiler BJ. Exposure of babies to C15-C45 mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. 2003Abstract
  6. Livingstone V, Stringer LJ. The treatment of Staphyloccocus aureus infected sore nipples: a randomized comparative study. J Hum Lact. 1999Abstract