Is Nimodipine compatible with breastfeeding? Do we have alternatives for Nimodipine?

Nimodipine

September 30, 2014 (Very Low Risk)

Excreted into breast milk in a non-significant amount.

Because of pharmacokinetic data (high protein-binding capacity and low oral bioavailability) the observed low excretion into breast milk would be explained.

Nimodipine does not alter secretion of Prolactin.

Alternatives

We do not have alternatives for Nimodipine since it is relatively safe.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • ニモジピン
  • نيموديبين
  • νιμοδιπίνη
  • Нимодипин
  • 尼莫地平

References

  1. Malachias MV, Figueiredo CE, Sass N, Antonello IC, Torloni MR, Bortolotto MRF L. 7th Brazilian Guideline of Arterial Hypertension: Chapter 9 - Arterial Hypertension in pregnancy Arq Bras Cardiol. 2016Abstract Full text (link to original source) Full text (in our servers)
  2. Bayer. Nimodipine. Drug Summary. 2011 Full text (in our servers)
  3. MS-AgEspMedyPS. Nimodipino. Ficha técnica. 2004 Full text (in our servers)
  4. Carcas AJ, Abad-Santos F, de Rosendo JM, Frias J. Nimodipine transfer into human breast milk and cerebrospinal fluid. Ann Pharmacother. 1996Abstract
  5. Tonks AM. Nimodipine levels in breast milk. Aust N Z J Surg. 1995Abstract
  6. Formisano R, Falaschi P, Cerbo R, Proietti A, Catarci T, D'Urso R, Roberti C, Aloise V, Chiarotti F, Agnoli A. Nimodipine in migraine: clinical efficacy and endocrinological effects. Eur J Clin Pharmacol. 1991Abstract
  7. Haitas B, Joffe BI, Edelstein D, Panz V, Lamprey JM, Seftel HC. Calcium antagonists (nifedipine and nimodipine) and pituitary responses to thyrotropin releasing hormone stimulation. J Cardiovasc Pharmacol. 1986Abstract