Is Norfloxacin compatible with breastfeeding? Do we have alternatives for Norfloxacin?


June 30, 2015 (Very Low Risk)

Some published studies indicate that Norfloxacin is not excreted into breast milk. A short half life and low oral bioavailability are characteristics that suggest it is the safest quinolone-type antimicrobial to be used while breastfeeding.

Quinolone antibiotics are being used to treat infection in newborn infants without side effect reported. A small amount pass into breast milk but absorption by the child's gut is thought would be interfered by the calcium present in the milk.

Should Fluor-quinolone medication be used in breastfeeding mothers, Nofloxacin, Ofloxacin and Ciprofloxacin are considered to be of choice because a lower concentration in mother's serum.

Follow-up of the child for the appearance of diarrhea is recommended since one case of Colitis pseudomembranosa occurred in a breastfed child who was born premature and complicated with Necrotizing Enterocolitis.

Consider the possibility of false negative results of urine cultures among breastfed infants from treated mothers who are febrile.


We do not have alternatives for Norfloxacin since it is relatively safe.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.


  • نورفلوكساسين (Arabic)
  • Норфлоксацин (Cyrillic)
  • 诺氟沙星 (Chinese)
  • ノルフロキサシン (Japanese)


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