Is Noscapine compatible with breastfeeding? Do we have alternatives for Noscapine?

Noscapine

October 9, 2016 (Very Low Risk)

Centrally acting cough suppressor with properties and usage similar to dextromethorphan.

Its high plasma protein-binding capacity explains the observed negligible excretion into milk (Olsson 1986) and also because its low oral bioavailability the passage to infant plasma from ingested milk may be hindered.

American Academy of Pediatrics: medication usually compatible with breastfeeding.

Alternatives

We do not have alternatives for Noscapine since it is relatively safe.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • Camphoscapine
  • Narcotine
  • Noscapine Camsilate
  • Noscapine Hydrochloride

Writings

  • نوسكابين (Arabic)
  • Носкапин (Cyrillic)
  • 那可丁 (Chinese)
  • ノスカピン (Japanese)
  • C22H23NO7 (Molecular formula)

Drug trade names

References

  1. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001Abstract Full text (link to original source) Full text (in our servers)
  2. Karlsson MO, Dahlström B, Eckernäs SA, Johansson M, Alm AT. Pharmacokinetics of oral noscapine. Eur J Clin Pharmacol. 1990Abstract
  3. Karlsson MO, Dahlström B. Serum protein binding of noscapine: influence of a reversible hydrolysis. J Pharm Pharmacol. 1990Abstract
  4. Olsson B, Bolme P, Dahlström B, Marcus C. Excretion of noscapine in human breast milk. Eur J Clin Pharmacol. 1986Abstract
  5. Dahlström B, Mellstrand T, Löfdahl CG, Johansson M. Pharmacokinetic properties of noscapine. Eur J Clin Pharmacol. 1982Abstract