At latest update, relevant published data on excretion into breast milk were not found.
Absorption through the skin and mucosa is nil, in addition it is known to be almost nil via gastrointestinal tract. Hence, it is unlikely its appearance in the mother's plasma or the milk.
Authorized medication for use in small infants and newborns.
It is recommended to avoid putting creams, gels and other products for local use that could contain paraffin (mineral oil) on the nipple, in order to keep from absorbing it by the child.
WHO Model List of Essential Medicines (2002): compatible with breastfeeding.
We do not have alternatives for Nystatin since it is relatively safe.
Very Low Risk
Compatible. Not risky for breastfeeding or infant.
Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.
Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.
Very High Risk
Not recommended. Cessation of breastfeeding or alternative.
- Nystatin Gel
- Nystatin Vaginal Ovules
Drug trade names
- Fukangning (馥康宁)™
- Mycostatin (米可定)™
- Mykoderm Heilsalbe™
- Mykundex mono™
- Pediaderm AF™
- НІСТАТИНОВА МАЗЬ
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- Amir LH, Pirotta MV, Raval M. Breastfeeding--evidence based guidelines for the use of medicines. Aust Fam Physician. 2011Abstract Full text (link to original source) Full text (in our servers)
- Hoeger PH, Stark S, Jost G. Efficacy and safety of two different antifungal pastes in infants with diaper dermatitis: a randomized, controlled study. J Eur Acad Dermatol Venereol. 2010Abstract
- Concin N, Hofstetter G, Plattner B, Tomovski C, Fiselier K, Gerritzen K, Fessler S, Windbichler G, Zeimet A, Ulmer H, Siegl H, Rieger K, Concin H, Grob K. Mineral oil paraffins in human body fat and milk. Food Chem Toxicol. 2008Abstract
- Nystatin. Drug Summary. 2006 Full text (in our servers)
- Ilett KF, Kristensen JH. Drug use and breastfeeding. Expert Opin Drug Saf. 2005Abstract
- de Vries TW, Wewerinke ME, de Langen JJ. [Near asphyxiation of a neonate due to miconazole oral gel]. Ned Tijdschr Geneeskd. 2004Abstract
- Nistatina. Ficha técnica. 2004 Full text (in our servers)
- Noti A, Grob K, Biedermann M, Deiss U, Brüschweiler BJ. Exposure of babies to C15-C45 mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. 2003Abstract
- WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)
- Mactal-Haaf C, Hoffman M, Kuchta A. Use of anti-infective agents during lactation, Part 3: Antivirals, antifungals, and urinary antiseptics. J Hum Lact. 2001Abstract
- Brent NB. Thrush in the breastfeeding dyad: results of a survey on diagnosis and treatment. Clin Pediatr (Phila). 2001Abstract
- Hoover K. Breast pain during lactation that resolved with fluconazole: two case studies. J Hum Lact. 1999Abstract
- Bodley V, Powers D. Long-term treatment of a breastfeeding mother with fluconazole-resolved nipple pain caused by yeast: a case study. J Hum Lact. 1997Abstract
- Dhondt F, Ninane J, De Beule K, Dhondt A, Cauwenbergh G. Oral candidosis: treatment with absorbable and non-absorbable antifungal agents in children. Mycoses. 1992Abstract