Otilonium Bromide
Anticholinergic drug used as spasmolytic for functional gastrointestinal disorders.
At latest update relevant published data on excretion into breast milk were not found.
It acts locally on the intestinal mucosa. Absorption through the intestine is practically absent (Evangelista 2004, Catalogo 2008), with an excretion being almost 100% unmodified in feces that is determinant for the extremely low levels reached in the plasma (Zhao 2010: <0.02 mg / L), which causes the passage through breastmilk in significant amounts must be very unlikely.
Side effects are mild and very rarely seen.
Although anticholinergics may reduce milk production, however, because of its poor absorption it would not be the case with Otilonium.
Alternatives
We do not have alternatives for Otilonium Bromide since it is relatively safe.
Very Low Risk
Compatible. Not risky for breastfeeding or infant.
Low Risk
Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.
High Risk
Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.
Very High Risk
Not recommended. Cessation of breastfeeding or alternative.
Writings
- بروميد أوتيلونيوم (Arabic)
- Отилония Бромид (Cyrillic)
- 奥替溴铵 (Chinese)
- オチロニウムブロミド (Japanese)
- C29H43BrN2O4 (Molecular formula)
Drug trade names
References
- AEMPS. Otilonio. Ficha técnica. 2015 Full text (in our servers)
- Zhao YR, Ding L, Fan HW, Yu Y, Qi XM, Leng Y, Rao YK. Determination of the unstable drug otilonium bromide in human plasma by LC-ESI-MS and its application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2010Abstract
- Catalioto RM, Triolo A, Giuliani S, Altamura M, Evangelista S, Maggi CA. Increased paracellular absorption by bile salts and P-glycoprotein stimulated efflux of otilonium bromide in Caco-2 cells monolayers as a model of intestinal barrier. J Pharm Sci. 2008Abstract
- Evangelista S. Quaternary ammonium derivatives as spasmolytics for irritable bowel syndrome. Curr Pharm Des. 2004Abstract