Is Oxazepam compatible with breastfeeding? Do we have alternatives for Oxazepam?
Oxazepam
November 16, 2014 (Very Low Risk)
Short-acting benzodiacepine. Diazepam active metabolite.
Excreted into breast milk in non-significant level. No harm effects on breastfed infants have been shown.
Eventual and low dose use of benzodiacepines are compatible with breastfeeding.
Use the short-acting benzodiazepine and minimal effective dose as possible mostly in the neonatal period.
Check-up for infant sedation and feeding problems.
Bed-sharing is not recommended for mothers who are taking this medication.
Alternatives
We do not have alternatives for Oxazepam since it is relatively safe.
Very Low Risk
Compatible. Not risky for breastfeeding or infant.
Low Risk
Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.
High Risk
Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.
Very High Risk
Not recommended. Cessation of breastfeeding or alternative.
Drug trade names
- Adumbran™
- Alepam™
- Alopam™
- Anxiolit™
- Azutranquil™
- Benzotran™
- Durazepam™
- Limbial™
- Mirfudorm™
- Murelax™
- Noctazepam™
- Noripam™
- Novo Aerofil Sedante™
- Novoxapam™
- Opamox™
- Ox-Pam™
- Oxabenz™
- Oxahexal™
- Oxaline™
- Oxamin™
- Oxanid™
- Oxapam™
- Oxapax™
- Oxascand™
- Oxepam™
- Oxpam™
- Praxiten™
- Purata™
- Serax™ (Canada, United States of America)
- Serenal™
- Serenid Forte™
- Serepax™
- Seresta™
- Serpax™
- Sigacalm™
- Sobril™
- Suxidina™
- Tranquo™
- Uskan™
- Zapex™ (Canada)
References
- UNICEF UK Baby Friendly Initiative statement on Bed-sharing when parents do not smoke: is there a risk of SIDS? An individual level analysis of five major case-control studies. 2013 Full text (link to original source) Full text (in our servers)
- Kelly LE, Poon S, Madadi P, Koren G. Neonatal benzodiazepines exposure during breastfeeding. J Pediatr. 2012Abstract
- L.Landa Rivera, M.Díaz-Gómez, A.Gómez Papi, J.M.Paricio Talayero, C.Pallás Alonso, M.T.Hernández Aguilar, J.Aguayo Maldonado, J.M.Arena Ansotegui, S.Ares Segura, A.Jiménez Moya, J.J.Lasarte Velillas, J.Martín Calama, M.D.Romero Escós. El colecho favorece la práctica de la lactancia materna y no aumenta el riesgo de muerte súbita del lactante. Dormir con los padres. Rev Pediatr Aten Primaria. 14:53-60 2012 Full text (link to original source) Full text (in our servers)
- Amir LH, Pirotta MV, Raval M. Breastfeeding--evidence based guidelines for the use of medicines. Aust Fam Physician. 2011Abstract Full text (link to original source) Full text (in our servers)
- ABM - Comité de protocolos de la Academia médica de lactancia materna (Academy of Breastfeeding Medicine). Protocolo Clínico de la ABM #6: Lineamientos sobre la práctica de dormir al bebé junto con la madre y la lactancia materna Revisión, marzo de 2008. Breastfeeding Medicine 2008 Full text (link to original source) Full text (in our servers)
- ABM - The Academy of Breastfeeding Medicine Protocol Committee. ABM Clinical Protocol #6: Guideline on Co-Sleeping and Breastfeeding. Breastfeeding Medicine 2008Abstract Full text (link to original source) Full text (in our servers)
- UNICEF UK. Compartiendo la cama con tu bebé. Guía para madres que amamantan. Folleto 2006 Full text (in our servers)
- Rubin ET, Lee A, Ito S. When breastfeeding mothers need CNS-acting drugs. Can J Clin Pharmacol. 2004Abstract
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- Dusci LJ, Good SM, Hall RW, Ilett KF. Excretion of diazepam and its metabolites in human milk during withdrawal from combination high dose diazepam and oxazepam. Br J Clin Pharmacol. 1990Abstract Full text (in our servers)
- Sonne J, Loft S, Døssing M, Vollmer-Larsen A, Olesen KL, Victor M, Andreasen F, Andreasen PB. Bioavailability and pharmacokinetics of oxazepam. Eur J Clin Pharmacol. 1988Abstract
- Wretlind M. Excretion of oxazepam in breast milk. Eur J Clin Pharmacol. 1987Abstract
- Kemp J, Ilett KF, Booth J, Hackett LP. Excretion of doxepin and N-desmethyldoxepin in human milk. Br J Clin Pharmacol. 1985Abstract
- Abernethy DR, Greenblatt DJ, Ochs HR, Weyers D, Divoll M, Harmatz JS, Shader RI. Lorazepam and oxazepam kinetics in women on low-dose oral contraceptives. Clin Pharmacol Ther. 1983Abstract
- Kanto JH. Use of benzodiazepines during pregnancy, labour and lactation, with particular reference to pharmacokinetic considerations. Drugs. 1982Abstract
- Greenblatt DJ. Clinical pharmacokinetics of oxazepam and lorazepam. Clin Pharmacokinet. 1981Abstract