Is Penicillin G Procaine compatible with breastfeeding? Do we have alternatives for Penicillin G Procaine?

Penicillin G Procaine

December 2, 2014 (Very Low Risk)

At latest update on excretion into breast milk of Penicillin procaine published information was not found.

Mother plasma levels of Penicillin procaine have been shown to be lower than those of Penicillin G. Penicillin G is excreted into breast milk in non-significant amounts without side-effects observed among breastfed infants from treated mothers. Plasma levels in those infants were shown to be low or undetectable.

Penicillin is a broad spectrum antibiotic that is commonly used in Pediatrics and Neonatology with very good tolerance even in premature newborns.

Be aware of false negative results that may be obtained from infants with bacterial cultures when the mother is on antibiotics.

Eleventh WHO's Model List of Essential Drugs 2002: Compatible with breastfeeding.

Alternatives

We do not have alternatives for Penicillin G Procaine since it is relatively safe.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • ペニシリンGプロカイン塩
  • Procaine Benzylpenicillin
  • Прокаин Бензилпенициллин

Drug trade names

References

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  3. Nahum GG, Uhl K, Kennedy DL. Antibiotic use in pregnancy and lactation: what is and is not known about teratogenic and toxic risks. Obstet Gynecol. 2006Abstract
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  7. Nau H. Clinical pharmacokinetics in pregnancy and perinatology. II. Penicillins. Dev Pharmacol Ther. 1987Abstract
  8. Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy Perinatol. 1984Abstract
  9. ROZANSKY R, BREZINSKY A. The excretion of penicillin in human milk. J Lab Clin Med. 1949Abstract
  10. GREENE HJ, BURKHART B, HOBBY GL. Excretion of penicillin in human milk following parturition. Am J Obstet Gynecol. 1946Abstract