Pentosan Polysulfate Sodium

Sulfated polysaccharide of plant origin with anticoagulant and fibrinolytic properties similar to heparin. Topical, oral and parenteral administration (subcutaneous, intramuscular or intravenous).
Orally used for pain relief of the urinary tract on interstitial cystitis.
Topically used on superficial venous disorders, hemorrhoids and hematomas.

At latest update relevant published data on its excretion into breast milk were not found.

Because of a high molecular weight, excretion into breastmilk in significant amounts seems very unlikely.
A low or not at all oral bioavailability (Faaij 1999, Simon 2005) makes it seems difficult the pass into the infant’s plasma through the breast milk ingested, except for premature infants and immediate neonatal period, in which there may be an increased intestinal permeability.

Do not apply it on the chest to prevent the infant from ingesting it; if necessary, do it after a feeding and clean it up thoroughly with water before the next one.

Alternatives

We do not have alternatives for Pentosan Polysulfate Sodium since it is relatively safe.