Is Pinaverium Bromide compatible with breastfeeding? Do we have alternatives for Pinaverium Bromide?

Pinaverium Bromide

April 17, 2016 (Low Risk)

A Calcium channel blocker with spasmolytic activity on the intestine and antimuscarinic effects.

At latest update no published data were found on excretion into breast milk.
Pharmacokinetic data (moderately high molecular weight and high protein binding) make unlikely the passage into milk in significant amounts.
Its low oral bioavailability hinders its passage into infant's plasma from ingested milk, except in preterm infants and immediate neonatal period, since they may exhibit an increased intestinal permeability.

Anticholinergics may reduce milk production: take a minimum necessary dose and avoid prolonged treatment if decreased milk is observed.

Alternatives

We do not have alternatives for Pinaverium Bromide.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Writings

  • بروميد بينافيريوم (Arabic)
  • Пинаверия Бромид (Cyrillic)
  • 匹维溴铵 (Chinese)
  • ピナベリウムブロミド (Japanese)
  • C26H41Br2NO4 (Molecular formula)

References

  1. BGP. Pinaverium. Product Monograph. 2015 Full text (in our servers)
  2. Annaházi A, Róka R, Rosztóczy A, Wittmann T. Role of antispasmodics in the treatment of irritable bowel syndrome. World J Gastroenterol. 2014Abstract
  3. AEMPS. Pinaverio. Ficha técnica. 2014 Full text (in our servers)