Is Piperacillin + Tazobactam compatible with breastfeeding? Do we have alternatives for Piperacillin + Tazobactam?

Piperacillin + Tazobactam

July 20, 2017 (Very Low Risk)

Piperacillin (see specific info) is a ureidopenicillin similar to ticarcillin (see specific info).
Tazobactam is added as a beta-lactamase inhibitor with few clinical and pharmacokinetic effects similar to that of piperacillin.

It is excreted into breastmilk in a clinically insignificant amount (Baier 1982, Chaplin 1982, Wyeth 2007).

Because it lacks of oral bioavailability, seems difficult any pass to the infant’s plasma through the breast milk ingested, except on premature infants and immediate neonatal period, in which there may be an increased intestinal permeability.

Authorized use in infants and small infants (Chen 2009).

Be aware of the likelihood of false negative cultures of febrile infants whose mothers are on antibiotics, as well as the possibility of gastroenteritis due to imbalanced intestinal flora.


See below the information of this related product:

Alternatives

We do not have alternatives for Piperacillin + Tazobactam since it is relatively safe.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • Piperacillin Sodium + Tazobactam Sodium

Writings

  • πιπερακιλλίνη + ταζοβακτάμη (Greek)
  • تازوباكتام + بيبيراسيلين (Arabic)
  • Пиперациллин + Тазобактам (Cyrillic)
  • 哌拉西林 + 他唑巴坦 (Chinese)
  • ピペラシリン + タゾバクタムナトリウム (Japanese)
  • C23H27N5O7S,H2O + C10H11N4NaO5S (Molecular formula)

Drug trade names

References

  1. AEMPS. Piperacilina-Tazobactam. Ficha técnica 2015 Full text (in our servers)
  2. Chen HN, Lee ML, Yu WK, Lin YW, Tsao LY. Late-onset Enterobacter cloacae sepsis in very-low-birth-weight neonates: experience in a medical center. Pediatr Neonatol. 2009Abstract
  3. Wyeth. Piperacillin & Tazobactam Product Information. 2007 Full text (in our servers)
  4. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993Abstract
  5. Chaplin S, Sanders GL, Smith JM. Drug excretion in human breast milk. Adv Drug React Acute Poisoning Rev 1982; 1:255-87. 1982
  6. Baier R, Wolnik L, Puppel H et al. Piperacillin concentrations in milk and serum from lactating women. Proc ICAAC. 1982;203. Abstract 779 (in https://toxnet.nlm.nih.gov/newtoxnet/lactmed.htm) 1982
  7. Tjandramaga TB, Mullie A, Verbesselt R, De Schepper PJ, Verbist L. Piperacillin: human pharmacokinetics after intravenous and intramuscular administration. Antimicrob Agents Chemother. 1978Abstract