Is Polymyxin B Sulfate compatible with breastfeeding? Do we have alternatives for Polymyxin B Sulfate?

Polymyxin B Sulfate

July 14, 2015 (Very Low Risk)

Antibiotic drug that is usual topically used (Dermatology, ENT and Ophthalmology)

At latest update no published data on excretion into breast milk were found.

The small dose and low absorption to the plasma in a majority of preparations that are topically used on the eye, ear or skin make a significant excretion into the milk unlikely.
Its high molecular weight makes less probable an excretion into breast milk in significant amount.

Due to a poor oral bioavailability, appearance in the infant's plasma from ingested milk is regarded as nil or scanty, except in premature infants or during the immediate neonatal period who may show an increased intestinal absorption.

Polymyxin E or Colistin with a very similar molecular structure is excreted into breast milk in non-significant amount.

It is advisable to avoid the application of creams, gels and other products for local use that would contain paraffin (mineral oil) to prevent absorption by the infant.

Alternatives

We do not have alternatives for Polymyxin B Sulfate since it is relatively safe.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • Polymysin B Sulfate

References

  1. AEMPS. Oftalmowell. Ficha técnica. 2013 Full text (in our servers)
  2. José de Jesús Coria Lorenzo, Alfredo Morayta Ramírez, Yetzamin Gutiérrez Muñoz. Polimixinas en la era de la multidrogorresistencia. Revista de Enfermedades Infecciosas en Pediatría 2011;25(98):66-70. 2011 Full text (in our servers)
  3. Kwa AL, Lim TP, Low JG, Hou J, Kurup A, Prince RA, Tam VH. Pharmacokinetics of polymyxin B1 in patients with multidrug-resistant Gram-negative bacterial infections. Diagn Microbiol Infect Dis. 2008Abstract
  4. Concin N, Hofstetter G, Plattner B, Tomovski C, Fiselier K, Gerritzen K, Fessler S, Windbichler G, Zeimet A, Ulmer H, Siegl H, Rieger K, Concin H, Grob K. Mineral oil paraffins in human body fat and milk. Food Chem Toxicol. 2008Abstract
  5. Leachman SA, Reed BR. The use of dermatologic drugs in pregnancy and lactation. Dermatol Clin. 2006Abstract
  6. Noti A, Grob K, Biedermann M, Deiss U, Brüschweiler BJ. Exposure of babies to C15-C45 mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. 2003Abstract