Is Potassium Citrate compatible with breastfeeding? Do we have alternatives for Potassium Citrate?

Potassium Citrate

August 30, 2018 (Very Low Risk)

It is used orally and intravenously to alkalize urine in the treatment of renal lithiasis and tubular acidosis.
After absorption, it is metabolized to bicarbonate. It has very low toxicity at the usual therapeutic doses (AEMPS 2012).
It is also used as a food additive (E 332) to reduce acidity.

Since the last update we have not found published data on its excretion in breastmilk.

Potassium is an ion present in breastmilk (Allen 1991) at a concentration 6 to 7 times greater than that of plasma: 18.3 ± 5.7 mEq/L. Like other monovalent ions, it freely enters and exits milk, inversely to the concentration of lactose (Lawrence 2016 p119). In the body, it is found mostly within cells, with a plasma concentration within specific limits (3.5 to 5.5 mEq/L).

Experts consider it compatible with breastfeeding (Briggs 2018).

Only in rare cases of maternal disease with high concentration of potassium in maternal blood (hyperkalaemia), can it increase its concentration in breastmilk, in which case possible gastrointestinal disorders and elevated plasma levels should be monitored in the infant.

Alternatives

We do not have alternatives for Potassium Citrate since it is relatively safe.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • Tripotassium Citrate

Writings

  • κάλιο κιτρικό (Greek)
  • Лимоннокислый Калий (Cyrillic)
  • クエン酸カリウム (Japanese)
  • Potassium citrate (French)
  • C6 H5 K3 O7, H2 O (Molecular formula)
  • Tripotassium 2-hydroxypropane-1,2,3-tricarboxylate monohydrate (Chemical name)
  • A12BA02 (ATC Code/s)
  • E332 (E number)

References

  1. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. 11th edition (acces on line) 2017
  2. Lawrence RA, Lawrence RM. Breastfeeding. A guide for the medical profession. Eighth Edition. Philadelphia: Elsevier; 2016
  3. AEMPS. Citrato de potasio. Ficha técnica. 2012 Full text (in our servers)
  4. Mission Ph.C. Potassium Citrate. Drug Summary. 2010 Full text (in our servers)
  5. Allen JC, Keller RP, Archer P, Neville MC. Studies in human lactation: milk composition and daily secretion rates of macronutrients in the first year of lactation. Am J Clin Nutr. 1991Abstract