Is Prednicarbate compatible with breastfeeding? Do we have alternatives for Prednicarbate?

Prednicarbate

December 8, 2017 (Very Low Risk)

High potency topical steroid.

Since the last update we have not found published data on its excretion in breast milk.

Because of a low absorption through skin, 0.1 - 3% (Dermik 2010, Novag 1998), significant excretion into breast milk is unlikely.

Whenever a treatment for nipple eczema or dermatitis is required the lowest potency steroid compound should be used (hydrocortisone). It should be applied right after the feed to make sure it has disappeared before the next nursing occurs. Otherwise, wipe cream out with a clean gauze.

Do not continuously use for longer than a week. Reportedly, a case of mineral-steroid toxicity has occurred due to continuous use of cream on the nipple (De Stefano 1983).

It is advisable to avoid the application to the nipple of creams, gels and other topical products containing paraffin (mineral oil) so that the infant does not absorb them (Concin 2008, Noti 2003).

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Writings

  • بريدنيكاربات (Arabic)
  • Предникарбат (Cyrillic)
  • 泼尼卡酯 (Chinese)
  • プレドニカルバート (Japanese)
  • C27H36O8 (Molecular formula)
  • 11β,17,21-Trihydroxypregna-1,4-diene-3,20-dione 17-(ethyl carbonate) 21-propionate (Chemical name)
  • D07AC18 (ATC Code/s)

Drug trade names

References

  1. Dermik. Prednicarbate. Drug Summary. 2010 Full text (in our servers)
  2. Concin N, Hofstetter G, Plattner B, Tomovski C, Fiselier K, Gerritzen K, Fessler S, Windbichler G, Zeimet A, Ulmer H, Siegl H, Rieger K, Concin H, Grob K. Mineral oil paraffins in human body fat and milk. Food Chem Toxicol. 2008Abstract
  3. Noti A, Grob K, Biedermann M, Deiss U, Brüschweiler BJ. Exposure of babies to C15-C45 mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. 2003Abstract
  4. Novag. Prednicarbato. Ficha técnica. 1998 Full text (in our servers)
  5. De Stefano P, Bongo IG, Borgna-Pignatti C, Severi F. Factitious hypertension with mineralocorticoid excess in an infant. Helv Paediatr Acta. 1983Abstract