Pregabalin
Anti-epileptic drug with structural properties similar to Gabapentin. Also used in the treatment of anxiety disorders, neuropathic pain and fibromyalgia.
Oral administration in two - three daily doses.
It is excreted in breast milk in small amounts, probably not clinically significant (Lockwood 2016).
In a mother who took it during pregnancy, very high milk levels were found at 48 hours after birth, probably due to a transplacental passage (Ohman 2011).
No side effects were observed in the infant (Ohman 2011).
Slight difficulty of breastfeeding has been reported in 7% of newborns of mothers who were given a dose of pregabalin prior to cesarean section (El Kenany 2016).
Several authors and experts agree that the use of this medication is safe during lactation, monitoring possible side effects (drowsiness) in the infant (Crettenand 2018, Reece 2017, Davanzo 2013).
Because less experience has been published than with other drugs of the same group, alternatives that are known as safer should be considered of choice during the neonatal period or in case of preterm babies.
Alternatives
- Gabapentin (Very Low Risk)
Very Low Risk
Compatible. Not risky for breastfeeding or infant.
Low Risk
Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.
High Risk
Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.
Very High Risk
Not recommended. Cessation of breastfeeding or alternative.
Writings
- بريغابالين (Arabic)
- Прегабалин (Cyrillic)
- 普瑞巴林 (Chinese)
- プレガバリン (Japanese)
- Prégabaline (French)
- C8 H17 NO2 (Molecular formula)
- (S)-3-(Aminomethyl)-5-methylhexanoic acid (Chemical name)
- N03AX16 (ATC Code/s)
Drug trade names
- Algerica (Альгерика)™
- Alzain™
- Gatica™
- Lecaent™
- Lunel™
- Lyrica (Лирика)™
- Lyrica (乐瑞卡)™
- Lyrica™
- Mystika™
- Neuristan™
- PGB™
- Plenica™
- Prebanal™
- Prebictal™
- Pregagamma™
- Pregamid™
- Rewisca™
- АЛЬГЕРІКА
- ГАБАЛІН
- ГАБАНА
- ГАЛАРА
- ЕКЗИСТА
- ЗОНІК
- ЛІНБАГ
- ЛІРИКА
- ЛЮГАБАЛІН
- МАКСГАЛІН 150
- МАКСГАЛІН 75
- НЕОГАБІН 150
- НЕОГАБІН 75
- НЕУРОКЕМ 100
- НЕУРОКЕМ 150
- НЕУРОКЕМ 75
- ОГРАНІЯ
- ПАГАМАКС
- ПАФІЯ
- ПРЕГАБАЛІН
- ПРЕГАБАЛІН-ДАРНИЦЯ
- ПРЕГАБАЛІН-ЗН
- ПРЕГАБАЛІН-РІХТЕР
- ПРЕГАБІО
- ПРЕГАДОЛ
- СУДОРЕГА
- ТОРГАБАЛІН 150
- ТОРГАБАЛІН 75
References
- Crettenand M, Rossetti AO, Buclin T, Winterfeld U. [Use of antiepileptic drugs during breastfeeding : What do we tell the mother?] Nervenarzt. 2018Abstract
- Reece-Stremtan Sarah, Campos Matilde, Kokajko Lauren, and The Academy of Breastfeeding Medicine. Breastfeeding Medicine. ABM Clinical Protocol #15: Analgesia and Anesthesia for the Breastfeeding Mother, Revised 2017. Breastfeeding Medicine. 2017 Full text (link to original source) Full text (in our servers)
- Jacob S, Nair AB. An Updated Overview on Therapeutic Drug Monitoring of Recent Antiepileptic Drugs. Drugs R D. 2016Abstract Full text (link to original source) Full text (in our servers)
- El Kenany S, El Tahan MR. Effect of preoperative pregabalin on post-caesarean delivery analgesia: a dose-response study. Int J Obstet Anesth. 2016Abstract
- Lockwood PA, Pauer L, Scavone JM, Allard M, Mendes da Costa L, Alebic-Kolbah T, Plotka A, Alvey CW, Chew ML. The Pharmacokinetics of Pregabalin in Breast Milk, Plasma, and Urine of Healthy Postpartum Women. J Hum Lact. 2016Abstract
- EMA. Pregabalin. Drug Summary. 2015 Full text (in our servers)
- EMA. Pregabalina. Ficha técnica. 2015 Full text (in our servers)
- Davanzo R, Dal Bo S, Bua J, Copertino M, Zanelli E, Matarazzo L. Antiepileptic drugs and breastfeeding. Ital J Pediatr. 2013Abstract Full text (link to original source) Full text (in our servers)
- Ohman I, De Flon P, Tomson T. Pregabalin kinetics in the neonatal period, and during lactation. Epilepsia. 52 (Suppl 6):249-50 (poster 824). 2011 Full text (link to original source) Full text (in our servers)
- Bockbrader HN, Wesche D, Miller R, Chapel S, Janiczek N, Burger P. A comparison of the pharmacokinetics and pharmacodynamics of pregabalin and gabapentin. Clin Pharmacokinet. 2010Abstract