Is Pyrantel Embonate compatible with breastfeeding? Do we have alternatives for Pyrantel Embonate?

Pyrantel Embonate

October 20, 2016 (Very Low Risk)

Anthelmintic drug which is effective against intestinal nematodes (Ascaris lumbricoides, Enterobius vermiculaires, -pinworms-, Trichostrongylus spp, Ancylostoma or Necator -hookworms) and tissue nematodes.

At latest update relevant published data were not found on excretion into breast milk.

It is poorly absorbed from the gastrointestinal tract, reaching very low plasma concentrations (<0.04 micrograms / mL: Fasanmade 1994) and usually given on a single dose, so it will hardly reach a significant concentrations in breastmilk.
Given its minimum absorption, it has been authorized to be used in young infants.

WHO List of Essential Medicines 2002: compatible with breastfeeding.

Alternatives

We do not have alternatives for Pyrantel Embonate since it is relatively safe.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • Pyrantel Pamoate

Writings

  • πυραντέλη παμοϊκή-εμβονική (Greek)
  • Пирантела Эмбонат (Cyrillic)
  • ピランテルパモ酸塩 (Japanese)
  • C11H14N2S,C23H16O6 (Molecular formula)

References

  1. Porto I. Antiparasitic drugs and lactation: focus on anthelmintics, scabicides, and pediculicides. J Hum Lact. 2003Abstract
  2. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)
  3. Fasanmade AA, Akanni AO, Olaniyi AA, Fasanmade AA, Tayo F. Bioequivalence of pyrantel pamoate dosage forms in healthy human subjects. Biopharm Drug Dispos. 1994Abstract