Rabeprazole Sodium
At latest update, relevant information on excretion into breast milk was not found.
Due to a high serum-protein-binding capacity, excretion of Rabeprazole into breast milk in significant levels is unlikely.
Since it's neutralized by the acid pH of stomach, capsules with enteric coated granules are used. Because of this, it is thought that the small quantity of Rabeprazole that may reach the breast milk would be neutralized by infant's stomach. In addition, absorption is greatly decreased by the presence of food.
Both Omeprazole and Pantoprazole pertain to the same chemical group with similar pharmacokinetics that are excreted in non-significant amount into the breast milk.
No alteration on serum Prolactin level has been shown.
Alternatives
- Famotidine (Very Low Risk)
- Omeprazole (Very Low Risk)
- Pantoprazole (Very Low Risk)
Very Low Risk
Compatible. Not risky for breastfeeding or infant.
Low Risk
Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.
High Risk
Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.
Very High Risk
Not recommended. Cessation of breastfeeding or alternative.
Synonyms
- ραμπεπραζόλη νατριούχος
- Натрий Рабепразол
References
- Mahadevan U, Kane S. American gastroenterological association institute technical review on the use of gastrointestinal medications in pregnancy. Gastroenterology. 2006Abstract Full text (link to original source) Full text (in our servers)
- Richter JE. Review article: the management of heartburn in pregnancy. Aliment Pharmacol Ther. 2005Abstract Full text (in our servers)
- Dammann HG, Burkhardt F, Wolf N. The effects of oral rabeprazole on endocrine and gastric secretory function in healthy volunteers. Aliment Pharmacol Ther. 1999Abstract
- Yasuda S, Ohnishi A, Ogawa T, Tomono Y, Hasegawa J, Nakai H, Shimamura Y, Morishita N. Pharmacokinetic properties of E3810, a new proton pump inhibitor, in healthy male volunteers. Int J Clin Pharmacol Ther. 1994Abstract