Is Ranitidine compatible with breastfeeding? Do we have alternatives for Ranitidine?

Ranitidine

March 22, 2018 (Very Low Risk)

Drug which is commonly used in pediatric therapy even for newborn treatment.

Excreted in high amount into breast milk although infant intake is reportedly lower than usual therapeutic dose.

No side effects on breastfed babies have been reported.

Increase of Prolactin levels has been shown, yet it does not induce galactorrhea.

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • Ranitidine Hydrochloride

Writings

  • Ρανιτιδίνη (Greek)
  • رانيتيدين (Arabic)
  • Ранитидин (Cyrillic)
  • 雷尼替丁 (Chinese)
  • ラニチジン (Japanese)
  • C13 H22 N4 O3 S (Molecular formula)
  • NN-Dimethyl-5-[2-(1-methylamino-2-nitrovinylamino)ethylthiomethyl]furfurylamine (Chemical name)
  • A02BA02 (ATC Code/s)

Drug trade names

References

  1. Rowe H, Baker T, Hale TW. Maternal medication, drug use, and breastfeeding. Pediatr Clin North Am. 2013 Feb;60(1):275-94. 2013Abstract
  2. Mahadevan U, Kane S. American gastroenterological association institute technical review on the use of gastrointestinal medications in pregnancy. Gastroenterology. 2006Abstract Full text (link to original source) Full text (in our servers)
  3. Richter JE. Review article: the management of heartburn in pregnancy. Aliment Pharmacol Ther. 2005Abstract Full text (in our servers)
  4. Petit A, Piednoir D, Germain ML, Trenque T. [Drug-induced hyperprolactinemia: a case-non-case study from the national pharmacovigilance database]. Therapie. 2003Abstract
  5. Nice FJ, Snyder JL, Kotansky BC. Breastfeeding and over-the-counter medications. J Hum Lact. 2000Abstract
  6. Hagemann TM. Gastrointestinal medications and breastfeeding. J Hum Lact. 1998Abstract
  7. Lee JJ, Rubin AP. Breast feeding and anaesthesia. Anaesthesia. 1993Abstract Full text (link to original source) Full text (in our servers)
  8. Kearns GL, McConnell RF Jr, Trang JM, Kluza RB. Appearance of ranitidine in breast milk following multiple dosing. Clin Pharm. 1985Abstract
  9. Roberts CJ. Clinical pharmacokinetics of ranitidine. Clin Pharmacokinet. 1984Abstract
  10. Delitala G, Devilla L, Pende A, Canessa A. Effects of the H2 receptor antagonist ranitidine on anterior pituitary hormone secretion in man. Eur J Clin Pharmacol. 1982Abstract