Is Rocuronium compatible with breastfeeding? Do we have alternatives for Rocuronium?

Rocuronium

January 4, 2015 (Very Low Risk)

It is a non-depolarizing muscle relaxant drug with a peripheral action that is used as premedication for endotracheal intubation, general anesthesia and mechanical ventilation.

Breastfed infants have not shown any problem after 1.5 to 5 hours of anesthesia time period with Rocuronio (additional drugs like Propofol, Remifentanil and Xenon were used).

A high molecular weight may decrease excretion into breast milk as well as a rapid elimination time.

In addition, a low oral bioavailability makes unlikely a pass from ingested mother's milk onto the infant's plasma.

Rocuronium should not prevent a mother from breast feeding her baby shortly after recovering from an anesthesia if she is in good condition.

Alternatives

We do not have alternatives for Rocuronium since it is relatively safe.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • Org-9426
  • Rocuronium Bromide
  • بروميد روكورونيوم
  • ροκουρόνιο βρωμιούχο
  • Рокурония Бромид
  • 罗库溴铵
  • ロクロニウム臭化物

Drug trade names

References

  1. Dalal PG, Bosak J, Berlin C. Safety of the breast-feeding infant after maternal anesthesia. Paediatr Anaesth. 2014Abstract
  2. Stuttmann R, Schäfer C, Hilbert P, Meyer MR, Maurer HH. The breast feeding mother and xenon anaesthesia: four case reports. Breast feeding and xenon anaesthesia. BMC Anesthesiol. 2010Abstract Full text (link to original source) Full text (in our servers)
  3. Howie WO, McMullen PC. Breastfeeding problems following anesthetic administration. J Perinat Educ. 2006Abstract Full text (link to original source) Full text (in our servers)
  4. Ferriols Lisart R,Ferriols Lisart F. Farmacología clínica y usos terapéuticos del Mivacurio. Farm Hosp. 1997 Full text (in our servers)
  5. Spigset O. Anaesthetic agents and excretion in breast milk. Acta Anaesthesiol Scand. 1994Abstract