Is Sertaconazole Nitrate compatible with breastfeeding? Do we have alternatives for Sertaconazole Nitrate?

Sertaconazole Nitrate

June 10, 2018 (Very Low Risk)

An imidazole antifungal agent used topically as a skin cream or in the form of vaginal ovules.

Since the last update date we have not found published data on its excretion in breastmilk.

The mean plasma concentration after the application of 300 mg of vaginal sertaconazole was 1.79 ± 0.70 micrograms/L (Wang 2009).

Its insignificant or zero systemic absorption through vaginal mucosa or skin (Croxtall 2009, Wang 2009, Susilo 2006, Farré 1992) and its high plasma protein binding makes transfer to milk in significant quantities unlikely.

You should wash your hands well after application.

Do not apply on breast-nipple-areola or clean before breastfeeding.

Alternatives

We do not have alternatives for Sertaconazole Nitrate since it is relatively safe.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • Sertaconazole

Writings

  • Σερτακοναζόλη (Greek)
  • Сертаконазола Нитрат (Cyrillic)
  • セルタコナゾール硝酸塩 (Japanese)
  • C20H15Cl3N2OS,HNO3 (Molecular formula)
  • (±)-1-{2,4-Dichloro-β-[(7-chlorobenzo[b]thien-3-yl)methoxy]phenethyl}imidazole nitrate (Chemical name)
  • D01AC14 (ATC Code/s)
  • G01AF19 (ATC Code/s)

References

  1. Croxtall JD, Plosker GL. Sertaconazole: a review of its use in the management of superficial mycoses in dermatology and gynaecology. Drugs. 2009Abstract
  2. Wang Y, Pang L, Wu M, Ou N. A validated LC-MS/MS method for determination of sertaconazole nitrate in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2009Abstract
  3. Susilo R, Korting HC, Greb W, Strauss UP. Nail penetration of sertaconazole with a sertaconazole-containing nail patch formulation. Am J Clin Dermatol. 2006Abstract
  4. Farré M, Ugena B, Badenas JM, Márquez M, Roset P, Ortiz JA. Pharmacokinetics and tolerance of sertaconazole in man after repeated percutaneous administration. Arzneimittelforschung. 1992Abstract