Spironolactone
A diuretic which is antagonist of Aldosterone receptor and a potassium-sparing drug.
Excretion into breast milk is clinically non-significant and without side-effects observed in breastfed infants of treated mothers.
A medication which is used for treatment of infants even in the neonatal period.
It decreases slightly the secretion of Prolactin, however, instead other diuretic drugs, a suppressive effect on lactation has not been reported.
The American Academy of Pediatrics (2001) rates it as Medication Usually Compatible With Breastfeeding.
Eleventh WHO Model List of Essential Drugs 2002: Compatible with breastfeeding.
Alternatives
We do not have alternatives for Spironolactone since it is relatively safe.
Very Low Risk
Compatible. Not risky for breastfeeding or infant.
Low Risk
Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.
High Risk
Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.
Very High Risk
Not recommended. Cessation of breastfeeding or alternative.
Synonyms
- スピロノラクトン
- سبيرونولاكتون
- Спиронолактон
- 螺内酯
Drug trade names
- Aldactone™
- Alizar™
- Biolactona™
- Cardactona™
- Diacqua™
- Drimux A™
- Espimax™
- Espirolona™
- Expal™
- Hexalacton™
- Jenaspiron™
- Lanx™
- Modulactone™
- Normital™
- Osiren™
- Rediun-E™
- Rocanol™
- Spinoral™
- Spiractin™
- Spirix™
- Spirobene™
- Spirobeta™
- Spiroctan™
- Spirogamma™
- Spirohexal™
- Spirolon™
- Spironol™
- Spirono™
- Spiron™ (Denmark, Hungary)
- Spiro™
- Spirotone™
- Uractonum™
- Uridactone™
- Verospilactone (Верошпилактон)™
- Verospiron (Верошпирон)™
- Verospiron™
- Vivitar™
- Xenalon™
- ВЕРОШПІРОН
- СПІЛАКТОН
- СПІРОНОЛАКТОН
- СПІРОНОЛАКТОН САНДОЗ®
- СПІРОНОЛАКТОН-ДАРНИЦЯ
References
- Anderson PO. Treating Hypertension During Breastfeeding. Breastfeed Med. 2018Abstract
- Malachias MV, Figueiredo CE, Sass N, Antonello IC, Torloni MR, Bortolotto MRF L. 7th Brazilian Guideline of Arterial Hypertension: Chapter 9 - Arterial Hypertension in pregnancy Arq Bras Cardiol. 2016Abstract Full text (link to original source) Full text (in our servers)
- Butler DC, Heller MM, Murase JE. Safety of dermatologic medications in pregnancy and lactation: Part II. Lactation. J Am Acad Dermatol. 2014Abstract
- Nakhjavani M, Hamidi S, Esteghamati A, Abbasi M, Nosratian-Jahromi S, Pasalar P. Short term effects of spironolactone on blood lipid profile: a 3-month study on a cohort of young women with hirsutism. Br J Clin Pharmacol. 2009Abstract
- Ghanem FA, Movahed A. Use of antihypertensive drugs during pregnancy and lactation. Cardiovasc Ther. 2008Abstract Full text (link to original source) Full text (in our servers)
- WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)
- AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001Abstract Full text (link to original source) Full text (in our servers)
- Erenus M, Gürbüz O, Durmuşoğlu F, Demirçay Z, Pekin S. Comparison of the efficacy of spironolactone versus flutamide in the treatment of hirsutism. Fertil Steril. 1994Abstract
- Cusan L, Dupont A, Gomez JL, Tremblay RR, Labrie F. Comparison of flutamide and spironolactone in the treatment of hirsutism: a randomized controlled trial. Fertil Steril. 1994Abstract
- Vĕtr M, Sobek A. Low dose spironolactone in the treatment of female hyperandrogenemia and hirsutism. Acta Univ Palacki Olomuc Fac Med. 1993Abstract
- Phelps DL, Karim A. Spironolactone: relationship between concentrations of dethioacetylated metabolite in human serum and milk. J Pharm Sci. 1977Abstract