Streptodornase
Fibrinolytic enzyme obtained from hemolytic streptococcus strains. It is used topically with streptokinase to remove clots or purulent material from wounds or cavities (pleura, bladder).
There is no scientific support for the effectiveness of its oral administration, since there is evidence of its lack of oral absorption and absence of fibrinolytic properties when taken orally (Oliven 1981, Vonmoos 1979).
Since the last update we have not found published data on its excretion in breast milk, but given the lack of absorption when taken orally it is unlikely to be excreted in breast milk in significant amounts which furthermore would not be absorbed in the infant’s intestine.
Alternatives
We do not have alternatives for Streptodornase since it is relatively safe.
Very Low Risk
Compatible. Not risky for breastfeeding or infant.
Low Risk
Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.
High Risk
Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.
Very High Risk
Not recommended. Cessation of breastfeeding or alternative.
Synonyms
- Streptococcal Deoxyribonuclease
Writings
- στρεπτοδορνάση (Greek)
- ستربتودورناز (Arabic)
- Стрептодорназа (Cyrillic)
- 链道酶 (Chinese)
References
- Oliven A, Gidron E. Orally and rectally administered streptokinase. Investigation of its absorption and activity. Pharmacology. 1981Abstract
- Vonmoos PL, Straub PW. [Absorption and hematologic effect of streptokinase-streptodornase (varidase) after intracavital or oral administration]. Schweiz Med Wochenschr. 1979Abstract