Is Streptokinase compatible with breastfeeding? Do we have alternatives for Streptokinase?

Streptokinase

July 31, 2017 (Very Low Risk)

A fibrinolytic enzyme obtained from the culture of streptococcus strains. Administered intravenously to treat acute myocardial infarction, pulmonary embolism and deep-vein thrombosis.

It is also used topically with streptokinase to remove clots or purulent matter from wounds or cavities (pleura, bladder).

There is no scientific support for the effectiveness of its oral administration, since there is evidence of its lack of oral absorption and absence of fibrinolytic properties when taken orally (Oliven 1981, Vonmoos 1979).

Since the last update we have not found published data on its excretion in breast milk, but given the lack of absorption when taken orally, high molecular weight and very rapid elimination when administered intravenously, it is unlikely to be excreted in breast milk in significant quantities which furthermore would not be absorbed in the infant's intestine.

Alternatives

We do not have alternatives for Streptokinase since it is relatively safe.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • Plasminokinase

Writings

  • στρεπτοκινάση (Greek)
  • ستربتوكيناز (Arabic)
  • Стрептокиназа (Cyrillic)
  • 链激酶 (Chinese)
  • ストレプトキナーゼ (Japanese)

References

  1. Gemmill JD, Hogg KJ, Burns JM, Rae AP, Dunn FG, Fears R, Ferres H, Standring R, Greenwood H, Pierce D, et al. A comparison of the pharmacokinetic properties of streptokinase and anistreplase in acute myocardial infarction. Br J Clin Pharmacol. 1991Abstract
  2. Grierson DS, Bjornsson TD. Pharmacokinetics of streptokinase in patients based on amidolytic activator complex activity. Clin Pharmacol Ther. 1987Abstract
  3. Oliven A, Gidron E. Orally and rectally administered streptokinase. Investigation of its absorption and activity. Pharmacology. 1981Abstract
  4. Vonmoos PL, Straub PW. [Absorption and hematologic effect of streptokinase-streptodornase (varidase) after intracavital or oral administration]. Schweiz Med Wochenschr. 1979Abstract