Is Sulodexide compatible with breastfeeding? Do we have alternatives for Sulodexide?

Sulodexide

January 31, 2016 (Low Risk)

Heparin-like glycosaminoglycan which is a mixture of low molecular weight heparin (80%) and dermatan sulfate (20%) that has hypolipaemic and antithrombotic properties and used for treatment of venous insufficiency.
It does not have significant effects on coagulation but some protective properties on vascular endothelium is attributed.

At latest update on excretion into breast milk no published data were found.

Pharmacokinetic data (large volume of distribution and high molecular weight) make it unlikely the passage into milk in significant amounts.

Until more published data about this drug regarding breastfeeding is available, a safer alternative should be used, especially during the neonatal period and in case of prematurity.

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • Glucurono-2-amino-2-deoxyglucoglucan sulfate

Writings

  • سولوداكسيد (Arabic)
  • 舒洛地昔 (Chinese)
  • スロデキシド (Japanese)

Drug trade names

References

  1. AEMPS. Sulodexida. Ficha técnica. 2014 Full text (in our servers)
  2. Coccheri S, Mannello F. Development and use of sulodexide in vascular diseases: implications for treatment. Drug Des Devel Ther. 2013Abstract
  3. Harenberg J. Review of pharmacodynamics, pharmacokinetics, and therapeutic properties of sulodexide. Med Res Rev. 1998Abstract