Is Sulpiride compatible with breastfeeding? Do we have alternatives for Sulpiride?

Sulpiride

July 2, 2015 (Very Low Risk)

Dopamine-selective antagonist that increases Prolactin serum levels which is used as anti-psychotic, anti-depressant, anti-emetic and prokinetic agent.

Its property as galactogogue has been questioned because poor methodology used by published studies that intended to prove it.

Doses at 50 mg twice-a-day after early post-partum for four weeks have been used to stimulate initiation of lactation without adverse effects in the mother.

Excretion into breast milk is moderate, however, side-effects in breastfed infants from treated mothers were not observed.

Best galactagogue effect is attained by promoting frequent breastfeeding on-demand along with the use of a proper lactation technique. Effective support to breastfeeding mothers, woman empowerment related to her ability to breastfeed and self-confidence are important factors to reinforce before start using galactagogue drugs.

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Writings

  • سولبيريد (Arabic)
  • Сульпирид (Cyrillic)
  • 舒必利 (Chinese)
  • スルピリド (Japanese)
  • C15 H23 N3 O4 S (Molecular formula)

Drug trade names

References

  1. Mannion C, Mansell D. Breastfeeding self-efficacy and the use of prescription medication: a pilot study. Obstet Gynecol Int. 2012Abstract Full text (link to original source) Full text (in our servers)
  2. Muresan M. Successful relactation--a case history. Breastfeed Med. 2011Abstract
  3. ABM. Comité de Protocolos de la Academia Médica de Lactancia Materna. ABM Protocolo Clínico #9: Uso de Galactogogos para Iniciar o aumentar la tasa de secreción de Leche Materna. Breastfeed Med. 2011 Full text (link to original source) Full text (in our servers)
  4. ABM. Academy Of Breastfeeding Medicine Protocol Committee. ABM Clinical Protocol #9: Use of galactogogues in initiating or augmenting the rate of maternal milk secretion (First Revision January 2011). Breastfeed Med. 2011Abstract Full text (link to original source) Full text (in our servers)
  5. Zuppa AA, Sindico P, Orchi C, Carducci C, Cardiello V, Romagnoli C. Safety and efficacy of galactogogues: substances that induce, maintain and increase breast milk production. J Pharm Pharm Sci. 2010Abstract Full text (link to original source) Full text (in our servers)
  6. Bryant CA. Nursing the adopted infant. J Am Board Fam Med. 2006Abstract Full text (link to original source) Full text (in our servers)
  7. Lasich AJ. Sulpiride and breastfeeding. S Afr Med J. 2005Abstract Full text (link to original source) Full text (in our servers)
  8. Gabay MP. Galactogogues: medications that induce lactation. J Hum Lact. 2002Abstract
  9. Hallbauer U. Sulpiride (Eglonyl)--use to stimulate lactation. S Afr Med J. 1997Abstract
  10. Emery MM. Galactogogues: drugs to induce lactation. J Hum Lact. 1996Abstract
  11. Gravenor M. Sulpiride (Eglonyl)--use to stimulate lactation. S Afr Med J. 1996Abstract
  12. Bressolle F, Brès J, Fauré-Jeantis A. Absolute bioavailability, rate of absorption, and dose proportionality of sulpiride in humans. J Pharm Sci. 1992Abstract
  13. McMurdo ME, Howie PW, Lewis M, Marnie M, McEwen J, McNeilly AS. Prolactin response to low dose sulpiride. Br J Clin Pharmacol. 1987Abstract Full text (link to original source) Full text (in our servers)
  14. Hofmeyr GJ, Van Iddekinge B, Blott JA. Domperidone: secretion in breast milk and effect on puerperal prolactin levels. Br J Obstet Gynaecol. 1985Abstract
  15. Ylikorkala O, Kauppila A, Kivinen S, Viinikka L. Treatment of inadequate lactation with oral sulpiride and buccal oxytocin. Obstet Gynecol. 1984Abstract
  16. Polatti F. Sulpiride isomers and milk secretion in puerperium. Clin Exp Obstet Gynecol. 1982Abstract
  17. Ylikorkala O, Kauppila A, Kivinen S, Viinikka L. Sulpiride improves inadequate lactation. Br Med J (Clin Res Ed). 1982Abstract Full text (link to original source) Full text (in our servers)
  18. Aono T, Aki T, Koike K, Kurachi K. Effect of sulpiride on poor puerperal lactation. Am J Obstet Gynecol. 1982Abstract
  19. O'Leary RM. Sulpiride improves inadequate lactation. Br Med J (Clin Res Ed). 1982Abstract Full text (link to original source) Full text (in our servers)
  20. Wiesel FA, Alfredsson G, Ehrnebo M, Sedvall G. The pharmacokinetics of intravenous and oral sulpiride in healthy human subjects. Eur J Clin Pharmacol. 1980Abstract
  21. Aono T, Shioji T, Aki T, Hirota K, Nomura A, Kurachi K. Augmentation of puerperal lactation by oral administration of sulpiride. J Clin Endocrinol Metab. 1979Abstract
  22. Fondu F. [Sulpiride and lactation]. Brux Med. 1975Abstract
  23. Kato Y, Ohgo S, Chihara K, Imura H. Stimulation of human prolactin secretion by sulpiride. Endocrinol Jpn. 1975Abstract Full text (link to original source) Full text (in our servers)