Is Suxamethonium Chloride compatible with breastfeeding? Do we have alternatives for Suxamethonium Chloride?

Suxamethonium Chloride

January 10, 2015 (Very Low Risk)

Muscle-relaxant agent with a peripheric depolarizing action that is used for rapid endotracheal intubation procedures, which also has a transient effect.

At latest update, no relevant published data concerning excretion into breast milk were found.

Because of a very rapid half-life elimination period (less than 1 minute), a significant excretion into breast milk is unlikely.

Also, a low oral bioavailability renders the pass of this agent to the infant's plasma, highly unlikely.

Succinylcholine should not prevent a mother from breast feeding her baby shortly after recovering from an anesthesia if she is in a good condition.

List of Medicines (WHO-2002): compatible with Breastfeeding.

Alternatives

We do not have alternatives for Suxamethonium Chloride since it is relatively safe.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • Succicurarium Chloride
  • Succinylcholine
  • كلوريد سوكساميثونيوم
  • σουξαμεθόνιο χλωριούχο
  • Суксаметония Хлорид
  • 塩化サクシニルコリン
  • 氯琥珀胆碱

Drug trade names

References

  1. Howie WO, McMullen PC. Breastfeeding problems following anesthetic administration. J Perinat Educ. 2006Abstract Full text (link to original source) Full text (in our servers)
  2. Sener EB, Guldogus F, Karakaya D, Baris S, Kocamanoglu S, Tur A. Comparison of neonatal effects of epidural and general anesthesia for cesarean section. Gynecol Obstet Invest. 2003Abstract
  3. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)
  4. Kato M, Shiratori T, Yamamuro M, Haga S, Hoshi K, Matsukawa S, Jalal IM, Hashimoto Y. Comparison between in vivo and in vitro pharmacokinetics of succinylcholine in humans. J Anesth. 1999Abstract
  5. Torda TA, Graham GG, Warwick NR, Donohue P. Pharmacokinetics and pharmacodynamics of suxamethonium. Anaesth Intensive Care. 1997Abstract
  6. Spigset O. Anaesthetic agents and excretion in breast milk. Acta Anaesthesiol Scand. 1994Abstract
  7. Hoshi K, Hashimoto Y, Matsukawa S. Pharmacokinetics of succinylcholine in man. Tohoku J Exp Med. 1993Abstract Full text (link to original source) Full text (in our servers)