Is Terbutaline Sulfate compatible with breastfeeding? Do we have alternatives for Terbutaline Sulfate?

Terbutaline Sulfate

April 17, 2016 (Very Low Risk)

It is excreted into breast milk in clinically non-significant amount and neither clinical nor development problems were observed in infants whose mothers were treated with oral terbutaline.
Plasma levels of these infants were undetectable or very low.

Preferable preparations are inhaled bronchodilators since <10% of the dose is absorbed.

American Academy of Pediatrics: medication usually compatible with breastfeeding.

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Writings

  • Тербуталина Сульфат (Cyrillic)
  • テルブタリン硫酸塩 (Japanese)
  • (C12H19NO3)2,H2SO4 (Molecular formula)

Drug trade names

References

  1. Amir LH, Pirotta MV, Raval M. Breastfeeding--evidence based guidelines for the use of medicines. Aust Fam Physician. 2011Abstract Full text (link to original source) Full text (in our servers)
  2. National Asthma Education and Prevention Program Asthma and Pregnancy Working Group. Quick Reference from the Working Group Report on Managing asthma during pregnancy: recommendations for pharmacologic treatment-2004 update. 2004;1-12. 2004 Full text (link to original source) Full text (in our servers)
  3. National Asthma Education and Prevention Program Asthma and Pregnancy Working Group. Managing asthma during pregnancy: recommendations for pharmacologic treatment-2004 update. 2004;1-57. 2004 Full text (link to original source) Full text (in our servers)
  4. Cazzola M, Testi R, Matera MG. Clinical pharmacokinetics of salmeterol. Clin Pharmacokinet. 2002Abstract
  5. Nelson-Piercy C. Asthma in pregnancy. Thorax. 2001Abstract Full text (link to original source) Full text (in our servers)
  6. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001Abstract Full text (link to original source) Full text (in our servers)
  7. McDonald CF, Burdon JG. Asthma in pregnancy and lactation. A position paper for the Thoracic Society of Australia and New Zealand. Med J Aust. 1996Abstract
  8. Ellsworth A. Pharmacotherapy of asthma while breastfeeding. J Hum Lact. 1994Abstract
  9. Lindberg C, Boréus LO, de Château P, Lindström B, Lönnerholm G, Nyberg L. Transfer of terbutaline into breast milk. Eur J Respir Dis Suppl. 1984Abstract
  10. Lönnerholm G, Lindström B. Terbutaline excretion into breast milk. Br J Clin Pharmacol. 1982Abstract Full text (link to original source) Full text (in our servers)
  11. Boréus LO, de Château PU. Terbutaline in breast milk. Br J Clin Pharmacol. 1982Abstract Full text (link to original source) Full text (in our servers)