Trazodone
It is excreted into breast milk in clinically non-significant amount.
Not effects on the infant's physical and psychomotor development at both short or long-term were found.
Variable levels of Prolactin secretion (increment or lowering), which were non-significant, were found after the use of Trazodone.
Because there is less experience published than with other drugs of the same pharmacological group, it should be preferred the use of an alternative drug that is known to be safer in the neonatal period or prematurity.
Alternatives
- Sertraline Hydrochloride (Very Low Risk)
- Paroxetine (Very Low Risk)
Very Low Risk
Compatible. Not risky for breastfeeding or infant.
Low Risk
Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.
High Risk
Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.
Very High Risk
Not recommended. Cessation of breastfeeding or alternative.
Synonyms
- AF-1161
- Trazodone Hydrochloride
Writings
- τραζοδόνη υδροχλωρική (Greek)
- Тразодона Гидрохлорид (Cyrillic)
- トラゾドン塩酸塩 (Japanese)
Drug trade names
References
- Angelini. Trazodona. Ficha técnica. 2012 Full text (in our servers)
- Davanzo R, Copertino M, De Cunto A, Minen F, Amaddeo A. Antidepressant drugs and breastfeeding: a review of the literature. Breastfeed Med. 2011Abstract
- LaboPharm. Trazodone. Drug Summary. 2010 Full text (in our servers)
- Newport DJ, Ritchie JC, Knight BT, Glover BA, Zach EB, Stowe ZN. Venlafaxine in human breast milk and nursing infant plasma: determination of exposure. J Clin Psychiatry. 2009Abstract
- Misri S, Corral M, Wardrop AA, Kendrick K. Quetiapine augmentation in lactation: a series of case reports. J Clin Psychopharmacol. 2006Abstract
- Otani K, Yasui N, Kaneko S, Ishida M, Ohkubo T, Osanai T, Sugawara K, Fukushima Y. Trazodone treatment increases plasma prolactin concentrations in depressed patients. Int Clin Psychopharmacol. 1995Abstract
- Misri S, Sivertz K. Tricyclic drugs in pregnancy and lactation: a preliminary report. Int J Psychiatry Med. 1991Abstract
- Verbeeck RK, Ross SG, McKenna EA. Excretion of trazodone in breast milk. Br J Clin Pharmacol. 1986Abstract Full text (link to original source) Full text (in our servers)
- Roccatagliata G, Murialdo G, Albano C, Giovale M, Zauli C, Polleri A. Neuroendocrinological and clinical data upon trazodone treatment in depressed patients. Neuropsychobiology. 1982Abstract
- Rolandi E, Magnani G, Milesi GM, Barreca T. Effect of a psychoactive drug, trazodone, on prolactin secretion in man. Neuropsychobiology. 1981Abstract
- Roccatagliata G, De Cecco L, Rossato P, Albano C. Trazodone intravenously administered and plasma prolactin levels. Int Pharmacopsychiatry. 1979Abstract
- Mazzi C, Montanini R, Riva LP. [Action of trazodone on the secretion of pituitary hormones. Behavior of prolactin and somatotropin]. Minerva Med. 1979Abstract