Is Trazodone compatible with breastfeeding? Do we have alternatives for Trazodone?

Trazodone

July 1, 2015 (Very Low Risk)

It is excreted into breast milk in clinically non-significant amount.

Not effects on the infant's physical and psychomotor development at both short or long-term were found.

Variable levels of Prolactin secretion (increment or lowering), which were non-significant, were found after the use of Trazodone.

Because there is less experience published than with other drugs of the same pharmacological group, it should be preferred the use of an alternative drug that is known to be safer in the neonatal period or prematurity.

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • AF-1161
  • Trazodone Hydrochloride

Writings

  • τραζοδόνη υδροχλωρική (Greek)
  • Тразодона Гидрохлорид (Cyrillic)
  • トラゾドン塩酸塩 (Japanese)

References

  1. Angelini. Trazodona. Ficha técnica. 2012 Full text (in our servers)
  2. Davanzo R, Copertino M, De Cunto A, Minen F, Amaddeo A. Antidepressant drugs and breastfeeding: a review of the literature. Breastfeed Med. 2011Abstract
  3. LaboPharm. Trazodone. Drug Summary. 2010 Full text (in our servers)
  4. Newport DJ, Ritchie JC, Knight BT, Glover BA, Zach EB, Stowe ZN. Venlafaxine in human breast milk and nursing infant plasma: determination of exposure. J Clin Psychiatry. 2009Abstract
  5. Misri S, Corral M, Wardrop AA, Kendrick K. Quetiapine augmentation in lactation: a series of case reports. J Clin Psychopharmacol. 2006Abstract
  6. Otani K, Yasui N, Kaneko S, Ishida M, Ohkubo T, Osanai T, Sugawara K, Fukushima Y. Trazodone treatment increases plasma prolactin concentrations in depressed patients. Int Clin Psychopharmacol. 1995Abstract
  7. Misri S, Sivertz K. Tricyclic drugs in pregnancy and lactation: a preliminary report. Int J Psychiatry Med. 1991Abstract
  8. Verbeeck RK, Ross SG, McKenna EA. Excretion of trazodone in breast milk. Br J Clin Pharmacol. 1986Abstract Full text (link to original source) Full text (in our servers)
  9. Roccatagliata G, Murialdo G, Albano C, Giovale M, Zauli C, Polleri A. Neuroendocrinological and clinical data upon trazodone treatment in depressed patients. Neuropsychobiology. 1982Abstract
  10. Rolandi E, Magnani G, Milesi GM, Barreca T. Effect of a psychoactive drug, trazodone, on prolactin secretion in man. Neuropsychobiology. 1981Abstract
  11. Roccatagliata G, De Cecco L, Rossato P, Albano C. Trazodone intravenously administered and plasma prolactin levels. Int Pharmacopsychiatry. 1979Abstract
  12. Mazzi C, Montanini R, Riva LP. [Action of trazodone on the secretion of pituitary hormones. Behavior of prolactin and somatotropin]. Minerva Med. 1979Abstract