Is Tretinoin (topical use) compatible with breastfeeding? Do we have alternatives for Tretinoin (topical use)?

Tretinoin (topical use)

October 9, 2016 (Very Low Risk)

Retinoid, an acid form of vitamin A.

At latest update no published data on excretion into breast milk were found.
It is a normal component of breastmilk.

Because of the small dose used and poor absorption into plasma of most topical dermatological preparations, excretion into breastmilk in significant amount appears to be unlikely.

Do not apply on the breast, otherwise, wash it off thoroughly before next feed.

Systemic use (overall as an antineoplastic drug) while breastfeeding is absolutely contraindicated.

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • Retinoid Acid (topical use)
  • Vitamin A Acid (topical use)

Writings

  • τρετινοΐνη (Greek)
  • تريتينوئين (Arabic)
  • Третиноин (Cyrillic)
  • 维A酸 (Chinese)
  • トレチノイン (Japanese)
  • C20H28O2 (Molecular formula)
  • NSC-122758 (Experimental code/s)

Drug trade names

References

  1. Butler DC, Heller MM, Murase JE. Safety of dermatologic medications in pregnancy and lactation: Part II. Lactation. J Am Acad Dermatol. 2014Abstract
  2. Leachman SA, Reed BR. The use of dermatologic drugs in pregnancy and lactation. Dermatol Clin. 2006Abstract
  3. Morland-Schultz K, Hill PD. Prevention of and therapies for nipple pain: a systematic review. J Obstet Gynecol Neonatal Nurs. 2005Abstract
  4. Akhavan A, Bershad S. Topical acne drugs: review of clinical properties, systemic exposure, and safety. Am J Clin Dermatol. 2003Abstract
  5. van Hoogdalem EJ. Transdermal absorption of topical anti-acne agents in man; review of clinical pharmacokinetic data. J Eur Acad Dermatol Venereol. 1998Abstract