Is Trimethoprim compatible with breastfeeding? Do we have alternatives for Trimethoprim?

Trimethoprim

February 20, 2016 (Very Low Risk)

It is excreted in breast milk in clinically non-significant amount. No problems have been observed in infants whose mothers were treated.

Medication which is used in infants from the second month of age.

Take into account the possibility of negative false results of cultures from febrile infants whose mothers are taking antibiotics as well as the possibility of acute diarrhea due to imbalance of the intestinal flora.

The American Academy of Pediatric states that it is usually compatible with breastfeeding medication.
WHO List of Essential Medicines from 2002 has classified it as compatible with breastfeeding.

Alternatives

We do not have alternatives for Trimethoprim since it is relatively safe.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • TMP

Writings

  • τριμεθοπρίμη (Greek)
  • ثلاثي ميثوبريم (Arabic)
  • Триметоприм (Cyrillic)
  • 甲氧苄啶 (Chinese)
  • トリメトプリム (Japanese)
  • C14H18N4O3 (Molecular formula)

Drug trade names

References

  1. Butler DC, Heller MM, Murase JE. Safety of dermatologic medications in pregnancy and lactation: Part II. Lactation. J Am Acad Dermatol. 2014Abstract
  2. Mitrano JA, Spooner LM, Belliveau P. Excretion of antimicrobials used to treat methicillin-resistant Staphylococcus aureus infections during lactation: safety in breastfeeding infants. Pharmacotherapy. 2009Abstract
  3. Kaiser J, McPherson V, Kaufman L, Huber T. Clinical inquiries. Which UTI therapies are safe and effective during breastfeeding? J Fam Pract. 2007Abstract
  4. Forna F, McConnell M, Kitabire FN, Homsy J, Brooks JT, Mermin J, Weidle PJ. Systematic review of the safety of trimethoprim-sulfamethoxazole for prophylaxis in HIV-infected pregnant women: implications for resource-limited settings. AIDS Rev. 2006Abstract
  5. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)
  6. Chin KG, McPherson CE 3rd, Hoffman M, Kuchta A, Mactal-Haaf C. Use of anti-infective agents during lactation: Part 2--Aminoglycosides, macrolides, quinolones, sulfonamides, trimethoprim, tetracyclines, chloramphenicol, clindamycin, and metronidazole. J Hum Lact. 2001Abstract
  7. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001Abstract Full text (link to original source) Full text (in our servers)
  8. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993Abstract
  9. Fulton B, Moore LL. Antiinfectives in breastmilk. Part II: Sulfonamides, tetracyclines, macrolides, aminoglycosides and antimalarials. J Hum Lact. 1992Abstract
  10. Borderon E, Soutoul JH et al. [Excretion of antibiotics in human milk]. Med Mal Infect. 1975;5:373-6. 1975
  11. Miller RD, Salter AJ.\ The passage of trimethoprim/sulpha-methoxazole into breast milk and its significance. \ Proceedings of the 8th International Congress of Chemotherapy, Athens. Hellenic Soc Chemother. 1974;1:687. 1974
  12. Arnauld R, Soutoul JH, Gallier J et al. Etude du passage de la trimethprim dans le lait maternel.\ [Study on the passage of trimethoprin into mother's milk]. Ouest Med. 1972;25:959-64.4. 1972
  13. Rasmussen F.\ Mammary excretion of sulphonamides. Acta Pharmacol Toxicol 1958; 15: 139-48. 1958