Is Ursodeoxycholic Acid compatible with breastfeeding? Do we have alternatives for Ursodeoxycholic Acid?

Ursodeoxycholic Acid

October 20, 2014 (Very Low Risk)

Biliary salt that appears in low amount in the serum because it is absorbed to the portal circulation and completely excreted into biliary duct.

Excreted into breast milk in non-significant amount with no side-effects being observed among infants of treated mothers.

Medication that has been used for treatment of newborns and older infants.

Alternatives

We do not have alternatives for Ursodeoxycholic Acid since it is relatively safe.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • ウルソデオキシコール
  • Ursodiol
  • حمض يورسوديوكسيكوليك
  • ουρσοδεοξυχολικό οξύ
  • Урсодезоксихолевая Кислота
  • 熊去氧胆酸

References

  1. Efe C, Kahramanoğlu-Aksoy E, Yılmaz B, Ozseker B, Takcı S, Roach EC, Purnak T, Kav T, Ozaslan E, Wahlin S. Pregnancy in women with primary biliary cirrhosis. Autoimmun Rev. 2014Abstract
  2. Hjortø S, Skov L, Lykke JA. [Obstetric dermatoses.] Ugeskr Laeger. 2014Abstract
  3. Vítek L, Zelenková M, Brůha R. Safe use of ursodeoxycholic acid in a breast-feeding patient with primary biliary cirrhosis. Dig Liver Dis. 2010Abstract
  4. Mahadevan U, Kane S. American gastroenterological association institute technical review on the use of gastrointestinal medications in pregnancy. Gastroenterology. 2006Abstract Full text (link to original source) Full text (in our servers)
  5. Goh SK, Gull SE, Alexander GJ. Pregnancy in primary biliary cirrhosis complicated by portal hypertension: report of a case and review of the literature. BJOG. 2001Abstract Full text (link to original source) Full text (in our servers)
  6. Brites D, Rodrigues CM. Elevated levels of bile acids in colostrum of patients with cholestasis of pregnancy are decreased following ursodeoxycholic acid therapy [see comemnts]. J Hepatol. 1998Abstract
  7. Rudi J, Schönig T, Stremmel W. -Therapy with ursodeoxycholic acid in primary biliary cirrhosis in pregnancy-. Z Gastroenterol. 1996Abstract
  8. Bachrach WH, Hofmann AF. Ursodeoxycholic acid in the treatment of cholesterol cholelithiasis. part I. Dig Dis Sci. 1982Abstract