Is Valproic Acid compatible with breastfeeding? Do we have alternatives for Valproic Acid?

Valproic Acid

September 30, 2015 (Very Low Risk)

It is excreted in breast milk in clinically non-significant amount without problems in the short or long term in infants whose mothers were treated. Plasma levels of these infants were undetectable or very low. Cognitive development did not suffer any alteration.

An infant was presented with thrombocytopenic purpura and anemia who recovered after removing valproate in the mother. However, doubts were raised on whether it was instead a post-viral reaction that led to idiopathic thrombocytopenic purpura.

The administration of valproic acid does not affect prolactin levels.

The American Academy of Pediatrics rates it as usual compatible with breastfeeding medication.
WHO List of Essential Medicines 2002: compatible with breastfeeding.

Alternatives

We do not have alternatives for Valproic Acid since it is relatively safe.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • Divalproex Sodium
  • Magnesium valproate
  • Sodium Valproate
  • Valproate Pivoxil
  • Valproate Semisodium

Writings

  • βαλπροϊκό οξύ (Greek)
  • Вальпроевая Кислота (Cyrillic)
  • 丙戊酸 (Chinese)
  • バルプロ酸 (Japanese)
  • C8 H16 O2 (Molecular formula)

Drug trade names

References

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