Is Verapamil Hydrochloride compatible with breastfeeding? Do we have alternatives for Verapamil Hydrochloride?

Verapamil Hydrochloride

June 4, 2016 (Very Low Risk)

It is excreted in breast milk in clinically non-significant amount and no problems have been observed in infants whose mothers were receiving this treatment.
Plasma levels in these infants were undetectable or very low.

Verapamil may induce to an increase of plasma Prolactin levels.

American Academy of Pediatrics: usually compatible with breastfeeding medication.
WHO List of Essential Medicines 2002: compatible with breastfeeding.

Alternatives

We do not have alternatives for Verapamil Hydrochloride since it is relatively safe.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • Iproveratril

Writings

  • βεραπαμίλη υδροχλωρική (Greek)
  • Верапамила Гидрохлорид (Cyrillic)
  • ベラパミル塩酸塩 (Japanese)
  • C27H38N2O4,HCl (Molecular formula)

Drug trade names

References

  1. Malachias MV, Figueiredo CE, Sass N, Antonello IC, Torloni MR, Bortolotto MRF L. 7th Brazilian Guideline of Arterial Hypertension: Chapter 9 - Arterial Hypertension in pregnancy Arq Bras Cardiol. 2016Abstract Full text (link to original source) Full text (in our servers)
  2. Serrano Aguayo P, García de Quirós Muñoz JM, Bretón Lesmes I, Cózar León MV. Tratamiento de enfermedades endocrinológicas durante la lactancia. [Endocrinologic diseases management during breastfeeding.] Med Clin (Barc). 2015Abstract
  3. Davanzo R, Bua J, Paloni G, Facchina G. Breastfeeding and migraine drugs. Eur J Clin Pharmacol. 2014Abstract
  4. Rowe H, Baker T, Hale TW. Maternal medication, drug use, and breastfeeding. Pediatr Clin North Am. 2013 Feb;60(1):275-94. 2013Abstract
  5. Pringsheim T, Davenport W, Mackie G, Worthington I, Aubé M, Christie SN, Gladstone J, Becker WJ; Canadian Headache Society Prophylactic Guidelines Development Group. Canadian Headache Society guideline for migraine prophylaxis. Can J Neurol Sci. 2012Abstract Full text (in our servers)
  6. Jürgens TP, Schaefer C, May A. Treatment of cluster headache in pregnancy and lactation. Cephalalgia. 2009Abstract
  7. Krysiak R, Okopieh B, Herman ZS. [Verapamil-induced hyperprolactinemia--a case report]. Pol Arch Med Wewn. 2005Abstract
  8. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)
  9. Tan HL, Lie KI. Treatment of tachyarrhythmias during pregnancy and lactation. Eur Heart J. 2001Abstract Full text (link to original source) Full text (in our servers)
  10. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001Abstract Full text (link to original source) Full text (in our servers)
  11. Kelley SR, Kamal TJ, Molitch ME. Mechanism of verapamil calcium channel blockade-induced hyperprolactinemia. Am J Physiol. 1996Abstract
  12. Miller MR, Withers R, Bhamra R, Holt DW. Verapamil and breast-feeding. Eur J Clin Pharmacol. 1986Abstract
  13. Inoue H, Unno N, Ou MC, Iwama Y, Sugimoto T. Level of verapamil in human milk. Eur J Clin Pharmacol. 1984Abstract
  14. de Swiet M. Excretion of verapamil in human milk. Br Med J (Clin Res Ed). 1984Abstract Full text (link to original source) Full text (in our servers)
  15. Andersen HJ. Excretion of verapamil in human milk. Eur J Clin Pharmacol. 1983Abstract