Is Vigabatrin compatible with breastfeeding? Do we have alternatives for Vigabatrin?

Vigabatrin

February 9, 2016 (Very Low Risk)

Excreted into breast milk in a clinically non-significant amount.

Because of a low oral bioavailability the pass from the breast milk toward the infant's plasma is hampered, except in premature and newborn infants who may exhibit a higher intestinal absorption due to an increased permeability.

Alternatives

We do not have alternatives for Vigabatrin since it is relatively safe.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • 4-Amino-5-hexenoic Acid
  • γ-Vinyl Aminobutyric Acid
  • γ-Vinyl-GABA

Writings

  • βιγαμπατρίνη (Greek)
  • فيغاباترين (Arabic)
  • Вигабатрин (Cyrillic)
  • 氨己烯酸 (Chinese)
  • ビガバトリン (Japanese)
  • C6H11NO2 (Molecular formula)

Drug trade names

References

  1. Jacob S, Nair AB. An Updated Overview on Therapeutic Drug Monitoring of Recent Antiepileptic Drugs. Drugs R D. 2016Abstract Full text (link to original source) Full text (in our servers)
  2. Davanzo R, Dal Bo S, Bua J, Copertino M, Zanelli E, Matarazzo L. Antiepileptic drugs and breastfeeding. Ital J Pediatr. 2013Abstract Full text (link to original source) Full text (in our servers)
  3. Rubin ET, Lee A, Ito S. When breastfeeding mothers need CNS-acting drugs. Can J Clin Pharmacol. 2004Abstract
  4. Bar-Oz B, Nulman I, Koren G, Ito S. Anticonvulsants and breast feeding: a critical review. Paediatr Drugs. 2000Abstract
  5. Tran A, O'Mahoney T, Rey E, Mai J, Mumford JP, Olive G. Vigabatrin: placental transfer in vivo and excretion into breast milk of the enantiomers. Br J Clin Pharmacol. 1998Abstract Full text (link to original source) Full text (in our servers)