Is Vincamine compatible with breastfeeding? Do we have alternatives for Vincamine?

Vincamine

June 10, 2018 (Low Risk)

This is one of the alkaloids from the Vinca minor plant with vasodilatory properties. Indicated without sufficient evidence to increase cerebral circulation.
Administered orally 3 times a day.

It can trigger serious cardiac arrhythmias (Fauchier 1993, Dany 1981).

It has very few bibliographical references. It is classified as having low therapeutic efficacy (Canary Islands Health Service 2011, INSALUD 2001).

Since the last update date we have not found published data on its excretion in breastmilk.

Until there is more published data about this drug in relation to breastfeeding, safer alternatives may be preferred, especially during the neonatal period and in the case of prematurity.

It is a non-essential medication and even more so during breastfeeding. If you have to use it, you can minimize the risk by waiting to breastfeed, if possible, about 4 hours after the medication is taken.

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Writings

  • Βινκαμίνη (Greek)
  • فينكامين (Arabic)
  • Винкамин (Cyrillic)
  • 长春胺 (Chinese)
  • ビンカミン (Japanese)
  • C21 H26 N2 O3 (Molecular formula)
  • Methyl (3α,16α)-14,15-dihydro-14β-hydroxyeburnamenine-14-carboxylate (Chemical name)
  • C04AX07 (ATC Code/s)

Drug trade names

References

  1. Dirección General de Farmacia. Servicio Canario de la Salud. Listado de fármacos considerados de Utilidad terapéutica Baja (UTB). 2011 Full text (in our servers)
  2. Área de Gestión de Farmacia. Subdirección General de Atención Primaria. Instituto Nacional de la Salud (INSALUD). Utilidad terapéutica de los medicamentos financiados por el Sistema Nacional de Salud. 2001 Full text (in our servers)
  3. Fauchier JP, Fauchier L, Babuty D, Breuillac JC, Cosnay P, Rouesnel P. [Drug-induced ventricular tachycardia]. Arch Mal Coeur Vaiss. 1993Abstract
  4. Dany F, Merle L, Goudoud JC, Liozon F, Blanc P, Bouvot JC, Nicot G, Dangoumau J. [Cardiac toxicity of vincamine: a seven cases report of ventricular arrhythmias by parenteral administration of vincamine (author's transl)]. Therapie. 1981Abstract
  5. Lücker PW, Simon B, Talmont DM. [Pharmacokinetics of multilayer vincamine dragees. Study of normal subjects]. Arzneimittelforschung. 1978Abstract