Is Vitamin B6 compatible with breastfeeding? Do we have alternatives for Vitamin B6?

Vitamin B6

February 26, 2018 (Low Risk)

Daily allowance of vitamin B6 ranges from 2 to 3 mg (Ares 2015, Hall 2010, Chang 2002, Bender 1989). A balanced and varied diet is enough without a need for extra supplementation with this vitamin. Vitamin B6 deficiency is extremely rare since it is widely distributed in many foods.

In those cases where supplementation is required, it is recommended not to exceed 40 mg a-day (Hale 2017 p.817, Ares 2015).
Excessive doses (> 50-100 mg/day) and long-term administration (> 3 months) can cause neurological problems (ADRAC 2008, Bender 1989, Waterston 1987, Dalton 1987, Schaumburg 1983).

Concentration of vitamin B6 in the breast milk is directly related to the amount present in diet (Ooylan 2002) with the possibility of a high increment by an excessive consumption through the diet.
Concentration of vitamin B6 is higher in mature milk than in transition milk and in colostrum (Ren 2015)

There are controversial data on the capacity of a high dose of Pyridoxine to inhibit the secretion of Prolactin and suppress the milk production.

The American Academy of Pediatrics rates it as usually compatible with breastfeeding.
Eleventh WHO Model List of Essential Drugs: Compatible with breastfeeding at nutritional dose (WHO / UNICEF 2002).


We do not have alternatives for Vitamin B6.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.


  • Adermine
  • Codecarboxylase
  • Metadoxine
  • Pyridoxal Phosphate
  • Pyridoxamine Hydrochloride
  • Pyridoxine Hydrochloride
  • Pyridoxine Pidolate
  • Пиридоксина Гидрохлорид
  • ピリドキシン塩酸塩


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  2. Ren X, Yang Z, Shao B, Yin SA, Yang X. B-Vitamin Levels in Human Milk among Different Lactation Stages and Areas in China. PLoS One. 2015Abstract Full text (link to original source) Full text (in our servers)
  3. Ares Segura S, Arena Ansótegui J, Díaz-Gómez NM; en representación del Comité de Lactancia Materna de la Asociación Española de Pediatría. La importancia de la nutrición materna durante la lactancia, ¿necesitan las madres lactantes suplementos nutricionales? [The importance of maternal nutrition during breastfeeding: Do breastfeeding mothers need nutritional supplements?] An Pediatr (Barc). 2015Abstract Full text (link to original source) Full text (in our servers)
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  7. ADRAC. Adverse Drug Reactions Advisory Committee. High-dose vitamin B6 may cause peripheral neuropathy. Aust Adverse Drug React Bull 2008; 27: 14–15. 2008 Full text (link to original source) Full text (in our servers)
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