Is Alprazolam compatible with breastfeeding? Do we have alternatives for Alprazolam?

Alprazolam

November 16, 2014 (Low Risk)

Short-acting benzodiazepine.

A case of Abstinence Syndrome in a child after mother withhold of Alprazolam at 9 months and sedation among infants has been reported. Both circumstances indicate that excretion into breast milk - despite small (< 10% of maternal dose) - can achieve clinical significance. Hence, rapid acting and less excretion into breast milk should be preferred.

Most benzodiacepine drugs may decrease prolactin levels but Alprazolam increases it.

Short-term and low dose treatment is compatible with breastfeeding. Choise of a low dose and short-acting benzodiacepine is advisable especially in the post-partum period.

Be aware of somnolence and poor feeding in the child.

Bed-sharing is not recommended for mothers who are taking this medication.

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Drug trade names

References

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