Amantadine Hydrochloride

Antiviral used for treatment and prophylaxis of type-A Influenza. Since it is a dopamine agonist is also used to treat Parkinson’s disease.

At latest update relevant published data on excretion into breast milk were not found.

Because of large volume of distribution and low plasma level observed (Pacifici 1976), a passage of significant amount through breastmilk or side-effects on the infant are not likely to occur.

Amantadine reduces plasma levels of prolactin, it has been used to treat galactorrhea caused by the use of dopaminergic neuroleptic drugs (Siever 1981 Correa 1987, Marken 1992, Carvalho 2011), however there is not information about the effect on lactating mothers. Prolactin is important to milk production especially during the first few weeks within birth. Frequent and effective stimulation of the nipple by the infant is essential on the maintenance of breastfeeding.

Whether administered during breastfeeding, it would be advisable not to use it in the neonatal period and monitor milk production.

Alternatives

• Zanamivir (Very Low Risk)
• Oseltamivir Phosphate (Very Low Risk)