Is Argatroban compatible with breastfeeding? Do we have alternatives for Argatroban?

Argatroban

October 27, 2014 (High Risk)

On latest update relevant data on breastfeeding was not found. Absorption by the intestine is unknown.

Although a better known and safer alternative is preferred, because of short half-life a delay of 3-4 hours period after last dose would permit to minimize any risk.

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Drug trade names

References

  1. [No authors listed] Argatroban: for a few selected patients. Prescrire Int. 2013Abstract
  2. Yurdakök M. Fetal and neonatal effects of anticoagulants used in pregnancy: a review. Turk J Pediatr. 2012Abstract Full text (link to original source) Full text (in our servers)
  3. Walenga JM. An overview of the direct thrombin inhibitor argatroban. Pathophysiol Haemost Thromb. 2002Abstract Full text (in our servers)