Is Azathioprine compatible with breastfeeding? Do we have alternatives for Azathioprine?

Azathioprine

November 16, 2014 (Very Low Risk)

Even though it is metabolized to mercaptopurine, just tiny amounts of this drug have been found in breast milk (4 - 18 micrograms/liter).

Among several breastfed infants of mothers who were treated with Azathioprine failed to be detected in the blood nor side effects were found. Long-term infectious diseases were not more common among exposed infants.

Exposition would be minimized if nursing is resumed 3 hours after last dose.

Alternatives

We do not have alternatives for Azathioprine since it is relatively safe.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

References

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